4. Diagnosis – Malignant melanoma of anterior ciliary body and iris root, spindle cell type with invasion of Schlemm’s canal and collector channels – Secondary glaucoma

5. Iris melanoma Most common primary neoplasm of the iris Constitutes 5% to 8% of uveal melanoma Arise from the anterior border layer tissue Most iris melanomas are composed of spindle cells, therefore relatively benign. Mortality rate is 4 to 5%

6. Retina Cases

7. Case 6

8. Case History Two days prior to enucleation, a 6-yo Caucasian girl was first noted to have left leukocoria. Left eye was blind and was enucleated because of the clinical diagnosis of retinoblastoma. Right eye examination and family history were unremarkable.

9. Case History (Gross) 23x23x22 mm with 11mm of optic nerve attached. Anterior half of the optic nerve stump exhibited a fusiform swelling with a maximum diameter of 6 mm. Posterior to this, expansion the nerve stump was 3mm in diameter. Posterior segment of the eye transmitted light poorly.

10. Case History (Gross) Eye was opened horizontally. Cornea was clear and the anterior chamber deep. Chamber angle was open. Densely yellow lens was in place and intact.

11. Case History (Gross) Vitreous was displaced anteriorly by a large tumor of cottage-cheese consistency that occupied most of the posterior segment, sending ragged extensions anteriorly to the ora serrata. Extravasated blood was seen within the center of the tumor.

12. Case History (Gross) Retina was identified with difficulty. Disc was obscured by the mass. Choroid, sclera, and episcleral tissue were unremarkable.