1. UCI Progress MBIRN AHM

2. Progress Tool Development –FIPS and HID: Modifications to store derived data, including morphometric measures from Freesurfer Methods Development –DTI: Submitted paper: Setsu Wakana, Arvind Caprihan, Martina M. Panzenboeck, Michelle Perry, James H. Fallon, Randy L. Gollub, Kegang Hua, Jiangyang Zhang, Hangyi Jiang, Prachi Dubey, Ari Blitz, Peter van Zijl, Susumu Mori. 2006. Tractography-based Quantitative Analyses of White Matter Anatomy: Tracking Protocol, Reproducibility and Tract-Specific Quantification of Cerebral Hemisphere Tool Use –Segmentations of MCI 1.5T multisite dataset: 50 cases done from two sites and initial analyses begun

3. 22 subjects: Site 17 Clinical Scores (above): MMSE, ADAS, CDR, BDI, Sex, Age, Years of Education Segmentation of one-time MRIs via Freesurfer to yield segmentation statistics (below). Tool Use: Morphometric analyses of MCI data

4. Utilizing multivariate regression analysis employing weighted squares, currently we are working on evaluating the effects of depressive symptoms on various parts of the MCI brain. Additionally, in an effort at theoretical detection and developing tools to aid in the MCI to AD conversion discriminate, we are developing algorithms that predict the volumes of various brain regions and circuits for a more comprehensive glimpse at the MCI / AD realm. Lft Hippocampal Volume=20067.004-94.153(AGE)- 776.604(MMSEtotal)-1177.874(CDRtnbox)+ 741.069(MMSEtimeortn)+1180.511(MMSEplaceortn)+ 815.291(MMSEattn)+622.303(MMSErecl) Tool Use: Morphometric analyses of MCI data

5. To test the latest versions of Freesurfer MBIRN Facilitations: Longitudinal Analysis Getting a new Siemens 1.5T after a GE 1.5T: Replicate longitudinal analyses from Han, et al. 2006 *Test software compatibility with an external site *Ensure correct version of Freesurfer/system compatibility *Obtain updated version with support for mgz image format Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S, Busa E, Pacheco J, Albert M, Killiany R, Maguire P, Rosas D, Makris N, Dale A, Dickerson B, Fischl B. Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage. 2006 Aug 1;32(1):180-94. Epub 2006 May 2. *Freesurfer reconstruction using Han’s longitudinal program *Acquire Global mean thickness values and surface thickness measures for variability comparisons ?

6. 6 subjects across 8 scans, 4 sessions, and 2 scanners GE scanner conversion to Siemens scanner Reconstruction of T1 images with Freesurfer v. 3.0.3 Determine between session and within session variability Preliminary results - GE only MBIRN Facilitations: Longitudinal Analysis

7. MBIRN-related collaborations FBIRN Group Analysis of morphometry using Freesurfer Fig.1Fig.2 -Fig.1: ‘Average’ subject w/ regions of t-ratios, above set threshold of 1.71. -Fig.2: Plot of correlation between subject class and cortical thickness. -ROI contains 159 vertices - Areas of the left hemisphere in which controls showed thicker grey matter measures than did schizophrenic patients, in a dataset of schizophrenic (n= 13) and control (n= 12) each from UCI. Analyzed using Freesurfer. Submitted to ICOSR 2007.

8. DTI Study

9. slicetimer nifti_tool Fips-mc-fsl Fips-sm2-fsl Fips-stc-fsl Fips-b0c-fsl aTaskData B0_mag DerivedDataA DerivedDataD DerivedDataC DerivedDataB avwmerge avwmaths++ mcflirt nifti_tool mri_fwhm ip_32R nifti_tool bet prelude fugue flirt fugue nifti_tool FIPS_MBTS_preprocs B0_phase SourceData DerivedData Transform Sub-transform Legend