1. Genotype: Col-0 and tt4 Light: CO1 and UV1 PlateGenotypeLightPlateGenotypeLightPlateGenotypeLight PlateGenotypeLightPlateGenotypeLightPlateGenotypeLight Genotype: Col-0 and tt5 Light: CO1 and UV1 Genotype: Col-0 and sng1 Light: CO1 and UV1 Genotype: Col-0 and sng1 Light: CO4 and UV4 Genotype: Col-0 and tt5 Light: CO4 and UV4 Genotype: Col-0 and tt4 Light: CO4 and UV4 Log 10 (q-value) Figure S1

2. WT, CO4 tt4, CO4 tt5, CO4 sng1, CO4 WT, UV4 tt4, UV4 tt5, UV4 sng1, UV4 WT, LC tt4, LC tt5, LC sng1, LC PC1, 25.1% PC2, 7.4% Figure S2

3. <5 <2 <1.25 <0.8 <0.5 <0.2 WT tt5 in LC Figure S3 <5 <2 <1.25 <0.8 <0.5 <0.2 WT tt4 tt5 sng1 in LC

4. A B in CO4 tt4sng1 in CO1 Figure S4 4-MSOB Galactronate Raffinose Garactotinol Sucrose Mannose Ascorbate Threonate Threonic acid-lac Xylose Dehydroascorbate 5-MSOP Gluconate Glucose ArabinoseRhamnose RiboseFructose Hexadecanoate Iinoleate Suberate Tetradecanoate 6-MSOH G6P Glycerol-3P Maltose 7-MSOH Trehalose Glycerate3P F6P IndoleGLS IndoleOMeGLS1 IndoleOMeGLS2 Glycerol Inositol 8-MSOOF6PPIndoleACN GSH Glycine Serine GlycerateInositol-1PTryptophanTryptamine Sinapoyl Mal1 3PGA LeucineShikimate Tyrosine  -Tocopherol Tyramine 4-MTB L-Cystine Cysteine Sinapoyl Mal2 PEP Valine AlanineQuinate Phenylalanine Bezoic acid Salicylate 5-MTP Threonine Pyruvate Isoleucine Lactate Ethanolamine Triethanolamine Cou-agmatine 6-MTH Methionine Sinapate Acetyl-CoA Glutarate Caffeic acid 7-MTH HomoSerine Nicotianamine Oxaloacetate Citrate Itaconate Lysine Campesterol Quer F5 8-MTO  -Alanine Malate cis-Aconitate Kaem F1  Sitosterol Quer F6 Aspartate Glyoxylate Uracil Nicotinate Fumarate isocitrate Kaem F2 Oleate Glycolate Asparagine Succinate 2-oxoglutarate Kaem F3 Antho_A9 Octadecatrienoate Arginine Succinyl-CoA GABA Antho_A10 Ornithine Glutamate Glutamine Histidine Threitol Me-thioadenosine Antho_A11 Putrescine Hydroxylamine Proline PhytolPhosphate Citrulline 4-MSOB Galactronate Raffinose Garactotinol Sucrose Mannose Ascorbate Threonate Threonic acid-lac Xylose Dehydroascorbate 5-MSOP Gluconate Glucose ArabinoseRhamnose RiboseFructose Hexadecanoate Iinoleate Suberate Tetradecanoate 6-MSOH G6P Glycerol-3P Maltose 7-MSOH Trehalose Glycerate3P F6P IndoleGLS IndoleOMeGLS1 IndoleOMeGLS2 Glycerol Inositol 8-MSOOF6PPIndoleACN GSH Glycine Serine GlycerateInositol-1PTryptophanTryptamine Sinapoyl Mal1 3PGA LeucineShikimate Tyrosine  -Tocopherol Tyramine 4-MTB L-Cystine Cysteine Sinapoyl Mal2 PEP Valine AlanineQuinate Phenylalanine Bezoic acid Salicylate 5-MTP Threonine Pyruvate Isoleucine Lactate Ethanolamine Triethanolamine Cou-agmatine 6-MTH Methionine Sinapate Acetyl-CoA Glutarate Caffeic acid 7-MTH HomoSerine Nicotianamine Oxaloacetate Citrate Itaconate Lysine Campesterol Quer F5 8-MTO  -Alanine Malate cis-Aconitate Kaem F1  Sitosterol Quer F6 Aspartate Glyoxylate Uracil Nicotinate Fumarate isocitrate Kaem F2 Oleate Glycolate Asparagine Succinate 2-oxoglutarate Kaem F3 Antho_A9 Octadecatrienoate Arginine Succinyl-CoA GABA Antho_A10 Ornithine Glutamate Glutamine Histidine Threitol Me-thioadenosine Antho_A11 Putrescine Hydroxylamine Proline PhytolPhosphate Citrulline <5 <2 <1.25 <0.8 <0.5 <0.2 WT tt4 tt5 sng1 <5 <2 <1.25 <0.8 <0.5 <0.2 WT tt5 tt4sng1 in CO4 in CO1

5. Figure S5

6. PC1, 62.6% PC2, 11.5% WT, CO tt4, CO sng1, CO WT, UV tt4, UV sng1, UV Figure S6

7. A. Photosynthesis WT tt4 sng1 Figure S7A

8. B. NDP sugar and ascorbate WT tt4 sng1 Figure S7B

9. C. Ribosomal protein overview WT tt4 sng1 Figure S7C

10. WT tt4 sng1 D. Tetrapyrrole metabolismFigure S7D