1. globus.org/genomics Globus Galaxies Science Gateways as a Service Ravi K Madduri, University of Chicago and Argonne National Laboratory madduri@uchicago.edu @madduri

2. globus.org/genomics Provide more capability for more people at lower cost by delivering “Science as a service” www.globus.org Our vision for a 21st century discovery infrastructure

3. globus.org/genomics An Old Idea: Service Oriented Science

4. globus.org/genomics Two Broader Themes Productivity of Researchers –Time spent performing administrative tasks Vs time spent doing science –Reproducibility Sustainability of scientific software –Reduction in funding for science

5. globus.org/genomics Our Science Stack Galaxy –Interactive execution –Creation, Execution, Sharing, Discovering Workflows Globus –Data management –Identity Management AWS, NERSc, Magellan –Chef, EC2, EBS, S3, SNS, NEWT –Spot, Route 53, Cloud Formation SaaS PaaS IaaS

6. globus.org/genomics Data Source Data Source Data Destinatio n Data Destinatio n User initiates transfer request 1 1 Globus moves and syncs files 2 2 Globus notifies user 3 3 Globus: Fast, reliable data transfer

7. globus.org/genomics Globus: Federated identity

8. globus.org/genomics Metadata Access Control License Storage Curation Workflow Curation Workflow Policies Collection Globus: Data publication service Metadata Data Metadata Data Metadata Data Dataset Community

9. globus.org/genomics Flexible, scalable, affordable genomics analysis for all biologists

10. globus.org/genomics Globus Genomics Sequencing Centers Public Data Public Data Storage Local Cluster/ Cloud Seq Center Research Lab Globus Provides a High-performance Fault-tolerant Secure file transfer Service between all data-endpoints Data ManagementData Analysis Picard GATK Fastq Ref Genome Alignment Variant Calling Galaxy Data Libraries Globus Genomics on Amazon EC2 Analytical tools are automatically run on the scalable compute resources when possible Globus Integrated within Galaxy Web-based UI Drag-Drop workflow creations Easily modify Workflows with new tools Galaxy Based Workflow Management System FTP, SCP, others FTP, SCP SCP Globus Genomics FTP, SCP, HTTP

11. globus.org/genomics Core Capabilities Computational profiles for various analysis tools to provide optimal performance Resources can be provisioned on-demand with Amazon Web Services cloud based infrastructure High performance, Reliable Data movement is streamlined with integrated Globus file-transfer functionality Integrated Globus endpoints and Campus login

12. globus.org/genomics Globus Galaxies - FACE-IT

13. globus.org/genomics Globus Galaxies - eMatter

14. globus.org/genomics Cardio Vascular Research Grid – Dr. Winslow @ Hopkins

15. globus.org/genomics Cosmology - PDACS

16. globus.org/genomics Sustainability Our goal is to build services that live beyond a funded proposals Two pricing options and multiple usage tiers. –Targeted users include individual research groups and bioinformatics cores –Platform pricing (includes only subscription to the Globus Genomics platform) –Bundled pricing (includes Globus Genomics platform subscription and AWS usage costs)

17. globus.org/genomics Our work is supported by: U.S. DEPARTMENT OF ENERGY 17

18. globus.org/genomics Thank you! @madduri