1. Topic: Modeling Inheritance Pedigree Charts

2. Related?  Cite evidence to indicate these two individuals are related.

3. Related?

4. TOOLS FOR MODELING INHERITANCE? Female Male

5. Connecting Pedigree Symbols  Married Couple  Siblings Examples of connected symbols:

6. What is a Pedigree?  A pedigree is a chart of the genetic history of family over several generations.  It shows the phenotypes of genetically related family members. It can also help determine genotypes.

7. Making a Pedigree  Female  Male  Married Couple  Siblings Filled in symbols indicate individual is affected with a disorder/trait

8. Pedigree  Let’s Analyze this pedigree

9. Example of a Pedigree You Parents Aunts, Uncles Grandparents Brother Do any disorders run in this family??

10. Interpreting a Pedigree Chart 2. Determine whether the disorder/trait is dominant or recessive. –If the disorder/trait is dominant, one of the parents must have the disorder. –If the disorder is recessive, neither parent has to have the disorder because they can be heterozygous.

11. Example of Pedigree Charts  Dominant or Recessive?

12. Answer  Dominant

13. Example of Pedigree Charts  Dominant or Recessive?

14. Answer  Recessive

15. Pedigree Charts I II III

16. Pedigree Chart -Cystic Fibrosis