1. Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy by Jeffrey S. Willey, Daniel N. Bracey, Patricia E. Gallagher, E. Ann Tallant, Walter F. Wiggins, Michael F. Callahan, Thomas L. Smith, and Cynthia L. Emory J Bone Joint Surg Am Volume 98(1):48-55 January 6, 2016 ©2016 by The Journal of Bone and Joint Surgery, Inc.

2. Representative force tracings measuring tension generated from the calf musculature at 5% and 10% strain. Jeffrey S. Willey et al. J Bone Joint Surg Am 2016;98:48-55 ©2016 by The Journal of Bone and Joint Surgery, Inc.

3. Stiffening of the calf complex after radiation therapy was prevented by the administration of Ang-(1-7). Jeffrey S. Willey et al. J Bone Joint Surg Am 2016;98:48-55 ©2016 by The Journal of Bone and Joint Surgery, Inc.

4. Interstitial and perivascular fibrosis after radiation therapy was prevented by the administration of Ang-(1-7). Jeffrey S. Willey et al. J Bone Joint Surg Am 2016;98:48-55 ©2016 by The Journal of Bone and Joint Surgery, Inc.

5. Ang-(1-7) treatment lowered TGF-β (top panel) and CTGF (bottom panel) concentrations versus radiation therapy alone as quantified by ELISA. Error bars represent the standard error of the mean. *p < 0.05; # indicates a nearly significant difference (p = 0.06). Jeffrey S. Willey et al. J Bone Joint Surg Am 2016;98:48-55 ©2016 by The Journal of Bone and Joint Surgery, Inc.