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Current Areas of Space-Related Health Research Skeletal Tissue Engineering - Adult mesenchymal stem cells - Nanobiomaterial scaffold - Bioreactor requirement.

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Presentation on theme: "Current Areas of Space-Related Health Research Skeletal Tissue Engineering - Adult mesenchymal stem cells - Nanobiomaterial scaffold - Bioreactor requirement."— Presentation transcript:

1 Current Areas of Space-Related Health Research Skeletal Tissue Engineering - Adult mesenchymal stem cells - Nanobiomaterial scaffold - Bioreactor requirement Presenter: Rocky S. Tuan, Ph.D., Chief, Cartilage Biology and Orthopaedics Branch Agency/Organization: NIAMS, NIH, DHHS COLUMBIA ST-48 The Effect of Microgravity on Calcium Metabolism and Bone Formation in Chick Embryo 1992 NASA SPACE SHUTTLE MISSION SPACELAB JSTS-47 PI: Tatsuo Suda (Showa University)

2 V Polymer Solution (  -Hydroxy Polyester) 18 kV Voltage Source Ground Polymer Cloud Electrospun nanofibers With seeded cells Seeded cells stained for cytoskeleton Application of Electrospun Nanofibrous Scaffold for Cell-Based Tissue Engineering

3 Dynamic Culture Promotes Tissue Integration Tissue-Engineered Cartilage Using Nanofibrous Scaffold, Human Adult Stem Cells, TGF- , and Bioreactor

4 Promising Areas for Space-Related Health Research Collaborations Understand the mechanisms responsible for randomized gravity mediated enhancement of stem cell-based cartilage formation Design novel bioreactors based on microgravity related principles for improved tissue engineering applications.

5 Existing Resources to Facilitate Space-Related Health Research Cartilage Biology and Orthopaedics Branch NIAMS, NIH Human resources - a unique consortium of biologists, engineers and surgeons Physical resources - instrumentation design and prototyping, mechanoactive bioreactors, biomaterial scaffold production, adult stem cell technologies, mechanical testing

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