1. Figure 1 T4 T3 T2 T1 M1 M2 T tumour deep surgical margin T4 T3

2. Photo- micrograph Figure 2 Sample T3T2T1M1M2M3 % Tumour 50 30000 Cygb meth17910000 p16 meth241110020 pTNMSiteOutcome T2N0M0Anterior TongueDisease Free Figure 2

3. Photo- micrograph Figure 3 Sample T4T3T2T1M1M2 % Tumour 8070 2000 Cygb meth958765 p16 meth31100546 pTNMSiteOutcome T2N0M0Buccal MucosaRecurrence 16/12 Figure 3

4. Photo- micrograph Figure 4 Sample T3T2T1M1M2N+N- % Tumour 406050001000 Cygb meth192118145260 p16 meth0000000 pTNMSiteOutcome T 2 N 2b MBase of TongueLocoregional recurrence Figure 4