1. World Map UNITED KINGDOM

2. AD Rate AD Changepoints Vaccines Paternal Age N/A Thimerosal N/A Diagnostic Substitution N/A Polio MMRVaricella Hep A UNITED KINGDOM (Click on the graphs under each topic)

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4. AD Changepoints Core & Atypical AD 1979 – 1992, <60mt olds:1988.6 Childhood AD 1979 – 1999, <10yr olds:1987 1988.6 1987 Go back to Main page

5. MMRII Vaccines Table of MMR vaccines used in the UK and AD changepoints MMRII immunization coverage for Birthyear 1989 to 2009 MMRII coverage and AD prevalence in UK (Click on the graphs under each topic) Go back to Main page

6. MEASLES, MUMPS, RUBELLA, VARICELLA 10/1988MMR IICombined measles, mumps and rubella with the RA 27/3 strain SmithKline Beecham, Merieux, Merck Sharpe >=12 monthsLicensed MMR II 1988.6 1987 MMR II MMR main page Go back to Main page

7. MMR main page Go back to Main page

8. MMR main page Go back to Main page

9. History of Polio vaccine used in UK 1956 IPV – Salk Introduced 1962 OPV-Sabin Introduced 1998-1999MedevaOPV (MRC-5) Introduced- Ended 2004PediacelCombined DTP-IPV cultured in Vero cell Sanofi Pasteur 2-10 months Introduced Go back to Main page

10. History of Hepatitis A vaccines approved for use in the U.K. 05/08/1994Havrix Monodose® The inactivated hepatitis A vaccine GSK>=16 years N/AVaqta Paediatric®Sanofi Pasteur MSD1-17 years N/AAvaxim®Sanofi Pasteur MSD>=16 years N/AHavrix Junior Monodose®GSK1-15 years 16/10/2006 Vaqta®Sanofi Pasteur MSD>=12 months 12/14/1999Epaxal®Crucell>=1year 09/20/1996 Twinrix Adult® A combined hepatitis A inactivated and hepatitis B vaccine GSK>=16 years N/ATwinrix Paediatric®GSK1-15 years N/AAmbirix®GSK1- 15 years N/AViATIM® A combined Hepatitis A and typhoid vaccine Sanofi Pasteur MSD>=16 years N/AHepatyrix®GSK>=15 years All Hep A vaccines in UK use MRC-5 human diploid cells Go back to Main page