1. Brucellosis
By dr.ahd samman

2. What is it?
Brucellosis is also called MALTA FEVER,it’s a zoonotic disease caused by brucella organism which enter the body through MOUTH,RESPIRATORY TRACT,GENITAL TRACT OR ABRADR SKIN.
HOW DOES IT SPREAD??
>>>spread is usually from from ingestion of RAW MILK FROM INFECTED CATTLE OR GOATS.
>>the Bacilli usually travel in the lymphatics and infect the L.N FOLLOWED BY haematogenous spread with localization in the RETICULOENDOTHELIAL SYSTEM .
>>>INCUBATION PERIOD 1-3 WEEKS.

3. CLINICAL FEATURES ONSET..
ACUTE>>with high continuous fever OR INSIDIOUS>>with fever undulating over 7-10 days .
SYMPTOMS..
Fever,sweating,weakness,headache,anorexia,PAIN IN LIMBS AND BACK,rigors,joint pains.
SIGNS..
*FEVER
*LYMPHADENOPATHY
*HEPATOSPLENOMEGALY
*SPINAL TENDERNESS

4. COMPLICATIONS *LOCALISED DISEASE..
Causing suppurative or granulomatous lesons including>>ARTHRITIS,SPONDYLITIS,BURSITIS,OSTEOMYELITITS,MENINGOENCEPHALITITS,
PNEUMONIA,HEPATITIS.
*CHRONIC BRUCELLOSIS..
LOW GRADE FEVER & NEUROPSYCHIATRIC SYMPTOMS.

5. INVESTIGATONS
*FOUR –FOLD OR GREATER RISE IN BRUCELLA ANTIBODY TITER OVER A PERIOD OF 4 WEEKS IS HIGHLY SUGGESTIVE OF BRUCELLOSIS.
*BLOOD&BONE MARROW C/S ARE POSITIVE IN 50% PATIENTS IN ACUTE ILLNESS.

6. MANAGMENT
*COMBINATION OF >>>DOXYCYCLINE 200mg daily + Rifampicin mg daily FOR 6 weeks.

7. THANK YOU