1. 1 INSPIRED DRIVEN COMMITTED VISION PRESENTATION APRIL 2015 BY DESIGN AORTIC

2. WerfenLife Barcelona, Spain Bolton Medical Florida, USA OUR HERITAGE

3. Technology Innovation to Enhance Patient Care

4. In rebranding themselves, WerfenLife has better reflected their passion to provide a better quality of life and forward thinking innovation. WerfenLife, the parent company of Bolton Medical, is dedicated to continual growth and fully committed to enhancing their business practices to provide better solutions for the healthcare industry. WerfenLife continues to fully support their companies to follow suit and develop state-of-the-art technologies and grow as global leaders in addressing the challenges of healthcare today.

5. 5 The Group started its activities in 1966 as a product distributor for the in vitro diagnostics market, under the name of IZASA. WERFENLIFE 2 WerfenLife is a 100% privately owned Spanish multinational, ranked among the top ten in vitro diagnostics companies worldwide. 1 In 1991 WerfenLife acquired INSTRUMENTATION LABORATORY in Lexington (EEUU), a leading company in the Hemostasis and Critical Care (Blood Gases) fields. 3 In 2002 started the Bolton Project, converging in Sunrise (Miami/USA) the manufacturing of interventional and endovascular (class III implantable prostheses). 4 In 2008 WerfenLife acquired INOVA, a leader company in the autoimmune disease diagnostics field through the research, development and reagent manufacturing. 5

6. 6 WERFENLIFE BUSINESS GROUPS WerfenLife is divided into 3 business groups:

7. 7 WERFENLIFE IS A GLOBAL COMPANY LIFE SCIENCE 3% MEDICAL DEVICES 16% IN VITRO DIAGNOSTICS 81% EEMEAI 7% LATAM 9% APAC 13% NA 21% EUROPE 50% Over $1.2 billion in revenue in 2014

8. 8 WE ARE BOLTON MEDICAL Bolton Medical, a WerfenLife company, aims to become the leading provider of endovascular solutions for aortic disease. Headquartered in the US, Bolton Medical improves the quality and safety in patient care by developing, manufacturing, and distributing innovative, high quality products and technology solely focused on the aorta.

9. 9 / WE ARE AORTIC BY DESIGN INSPIRED by a belief that quality designs lead to a better quality of life. DRIVEN by a passion and respect for the aortic anatomy. COMMITTED to crafting advanced endovascular solutions for every patient.

10. 10 To develop solutions focused solely on the aorta to enhance endovascular treatment for both physicians and patients. OUR MISSION

11. 11 OUR GLOBAL PRESENCE Direct Sales Distribution Patients treated w/ Relay Relay Cases: ~15,000 Treovance Cases: ~4,500 1,500 6,000 2,500 500 4,500

12. 12 Dual Sheath Delivery System Proximal Capture S-Bar Technology Self-Aligning Technology Engineered Textiles Proximal Conformability and Seal Active Fixation OUR APPROACH Our deliberate and anatomy specific development approach has allowed us to create core technology we can leverage: //////

13. 13 OUR CURRENT STATUS / // / We are growing closer to delivering on our vision of endovascular solutions for the entire aorta.

14. 14 CONTINUOUS INNOVATION & DEVELOPMENT BOLTON MEDICAL HISTORY 2005 RELAY CE Mark RELAY 250 2006 2007 RELAY NBS 2009 RELAY PLUS CE Mark 2013 TREOVANCE CE Mark TREOVANCE Custom Made Program FDA and PMDA approval of RELAY PLUS 2012 First in man with the RELAY 2004 2011 RELAY NBS CE Mark First Branch Experiences RELAY NBS PLUS CE Mark 2010 NEXT TREO, new Abdominal device CE Mark RELAY PRO is under review in Europe

15. 15 THORACIC PORTFOLIO: COMMERCIAL RELAY PRO 1.Leverages trendsetting RELAY technology 2.Enhances ease of use for accurate deployment 3.Lowers profile to treat more patients. RELAY PLUS/NBS 1.Designed specifically for the thoracic aorta 2.Enabled for precision 3.Broad portfolio to optimize procedure SYSTEM SPECS: Diameters: 22mm – 36mm Lengths: 100mm – 250mm Tapers: 4mm on all 150,200 & 250’s OD: 22F – 26F SYSTEM SPECS: Diameters: 22mm – 36mm Lengths: 100mm – 250mm Tapers: 4mm on all 150,200 & 250’s OD: 18F – 22F // RELAY PRO is under investigation in Europe and not FDA approved.

16. 16 THORACIC PORTFOLIO: CUSTOM Custom Configurations: Fenestrations Custom Stent Placement Custom Delivery Systems Proximal/Distal Scallops Custom Proximal/Distal Configurations Reverse Tapers Light/Extreme Tapers Custom Lengths Extreme Diameters Our custom program strives to deliver more endovascular options to patients with aortic disease. // The custom program is not available in the US

17. 17 ABDOMINAL PORTFOLIO: COMMERCIAL NEXT GEN TREOVANCE 1.Taking good to great 2.Provides a complete solution 3.Optimizes the procedure TREOVANCE 1.Customization within the portfolio 2.Designed for durability 3.Engineered for confidence SYSTEM SPECS: 3-piece System Main Body: 20mm – 36mm Limbs: 8mm – 24mm Main Body OD: 18F - 19F Limb OD: 15F-16F SYSTEM SPECS: 3-piece System Main Body: 20mm – 36mm Limbs: 8mm – 24mm Main Body OD: 18F - 19F Limb OD: 13F-14F // Next Gen TREOVANCE is not approved in the US NextGen TREOVANCE is under investigation in the US and pending approval in Europe

18. 18 ABDOMINAL PORTFOLIO: CUSTOM Custom Configurations: Tapers Reverse/Extreme Tapers Extreme Lengths Scallop Single Fenestration Double Fenestration Double Fenestration w/Scallop Our custom program strives to deliver more endovascular options to patients with aortic disease. // The custom program is not available in the US

19. 19 A SOLID PIPELINE OF PRODUCTS: TAA DOUBLE BRANCH “Off-the-shelf” Solution Based on RELAY® NBS PLUS platform Intended for Zone 0 deployment Bridge Stents will be Next Generation TREOVANCE inspired 33 Clinical Cases through Custom Program Commercialization Strategy being Pursued /

20. 20 A SOLID PIPELINE OF PRODUCTS: ASCENDING THORACIC DEVICE Based on RELAY ® NBS PLUS platform Optimized conformability Targeting broad applicability in Ascending Pathology 32 clinical cases performed through the Custom Program Commercialization Strategy being Pursued

21. 21 A SOLID PIPELINE OF PRODUCTS: VISCERAL THORACOABDOMINAL Development underway PARARENAL Development underway

22. 22 OUR CUSTOMERS

23. 23 INSPIRED DRIVEN COMMITTED THANK YOU