1. Lecture 24 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964

2. Regulation

4. Carbons for amino acids

5. Amino acids = More than proteins! Creatine Glutathione Heme Nitric oxide Hormones Neurotransmitters

6. Nucleotide synthesis from many molecules

7. Synthesis of purines…

8. …starts on a ribose molecule

9. A & G from I

10. Regulation of purine synthesis

11. Pyrimidine biosynthesis

12. Regulation

13. In the presence of CTP, enzyme changes: A. No change in kinetic parameters B. V max increases C. K m increases D. V max decreases, K m increases E. V max decreases, K m increases, k cat increases

14. Nucleotide metabolism… Still have a MAJOR question… A. Source of C and N for Pu and Py rings B. Regulation of synthesis C. NTP  dNTP D. NMP  NTP E. Difference between plants & animals

15. Oxy  deOxy

16. Regulation by reduction!

17. Regulation of ribonucleotide reductase

18. The deal with THF