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Published byRoberta Cooper Modified over 9 years ago
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Biomechanical Tissue Stimulator Group 1: Matt Brady (BME/EE) Ankeet Choxi (BME) Misha Kotov (CS) Steven Manuel (ME) Adviser: Dr. V. Prasad Shastri
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Overview Stimulates tissue mechanically Promotes growth of tissue engineered cartilage
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What are we stimulating? Articular cartilage covers human joint surfaces transfers mechanical load to skeletal system makes up ~2% of tissue volume in human body
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Persistent medical problems Limited ability to self-repair avascular Osteoarthrosis and related problems very common 100,000 AC injuries annually Arthritis 2 nd most common US disability $86 billion in medical expenses annually 21% of adults in US diagnosed with arthritis
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Why stimulate? Positive response to mechanical stimulation Biomechanical stimulator delivers controlled amount of force Measured results
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Past Work Ongoing cell-culture research project Prototype of stimulator has been constructed Many problems incurred Much research done for design of new device Range of force Sensors Detection and environment
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Current Work Finalizing design specifications Purchasing appropriate hardware/software Equipment consideration: Motor to drive device and design Controller system for motor Power Supply Multiple sensors Data Acquisition and Device Calibration
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Design Parameters Accuracy of 20 microns Stimulation frequency of 1 Hz max Max load of 1 MPa or 100 N per sample 12 wells at once Max in-test stroke of 1 mm 100 percent humidity at 98°F
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Well plate with samples Platen Stepper Actuator Teflon pistons Device Structure Samples
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Mechanical End Progress Completed finite element analysis and finalized fabrication parameters
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Mechanical End Progress Made significant progress toward an easy to fabricate custom contact sensor
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Programming objectives Program an application provide the following: Control the motor(s) Calibrate the sensors Gather relevant data Help on interface with standalone control unit
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LabVIEW! Acquire, analyze, present data Graphical development environment Measurement and control services Virtual instrumentation
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Application considerations Based on the number of samples, display appropriate distribution pattern Display where contact was made and with how much force; determine baseline displacement Allow for customized routines, be able to save and repeat procedures Update experiment figures in real time Provide exception handling routines Communication with standalone control unit
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Current Work Found some pre-programmed modules to control stepper motor Contacted National Instruments about an assigned application engineer Looked into interface with displacement sensors
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DAQ Card Reads data from the motor and sensors Keeps timing of device Outputs the step and direction into the driver which runs the motor Runs off LabView
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Motor Driver Driver takes inputs from the DAQ card and relays them to the motor Allows fractional stepping of motor Provides current limiting to keep motor from getting too hot and drawing too much power
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Power Supply Powers individual components of system Need to know what voltage and current each part runs on to determine what power supply can be used and for which components
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Power Supply Regulated 24V so motor runs at optimal voltage Connects to driver, which in turn powers motor Powers other components as well, however, resistors need to be used to lower voltage.
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Displacement Sensor Will output measurements of displacement Needed to determine amount of strain applied to each tissue sample Used as a tilt sensor
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Future Work Finalizing the device design Ordering necessary hardware to begin construction on device prototype Drawings and sketches of device design. Begin milling and construction of device frame. Program common compatibility of motors, sensors, drivers, and power supply. Begin phase testing
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Summary Articular cartilage and problems Biomechanical tissue stimulator Mechanically stimulates cartilage Promotes growth of tissue Design, considerations End Goal Be able to mechanically stimulate growing cartilage
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References Aufderheide, Adam C., Athanasiou, Kyriacos A. A Direct Compression Stimulator for Articular Cartilage and Meniscal Explants. (2006) Annals of Biomedical Engineering, Vol. 34. 1463-1474 Bobic,Vladimir. Current Status of the Articular Cartilage Repair biomed: The Journal of Regenerative Medicine Apr 2000, Vol. 1, No. 4: 37-41 Mansour JM. Biomechanics of Cartilage. (2004) Kinesiology: The Mechanics & Pathomechanics of Human Movement by Carol Oatis. 66- 79. Xia Y, Moody JB, Alhadlaq H. Orientational Dependence of T2 Relaxation in Articular Cartilage: a microscopic MRI study. (2002) Magnetic Resonance in Medicine 48: 460-469
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