1. Kronlab Glass Columns high quality glass columns
for lab scale to process scale
solvent resistant and/or biocompatible design
designed for low, medium and high pressure column chromatography

2. Product Lines Eco ECOPLUS Classic BioCart Pilot lab scale
low / medium pressure
ECOPLUS
extended pressure rating up to 80 bar
lab scale to prep
Classic
medium pressure
conical tube
BioCart
lab scale to prep
glass cartridges
medium to high pressure
Pilot
pilot scale to production scale
custom designed
solvent resistant or for aqueous buffers

3. Pilot Columns for Pilot to Production Scale

4. Pilot Columns for Pilot to Production Scale
designed for use in pilot and production scale
designed for use with organic solvents (version SR) or aqueous buffers (version AB)
outstanding flow distribution for a linear flow distribution profile
high precision manufacturing of plungers and distribution plates with CNC milling machines, no injection moulding involved

5. Pilot Columns for Pilot to Production Scale
full documentation for validation
full service and support for custom designed columns
materials are in compliance with FDA regulations CFR 21, certified if needed
precise and reliable height adjustment of the piston with hand wheels
mounted either on castors or fixed stand or directly into customer´s plant

6. Pilot Columns - Wetted Materials
column tube: calibrated borosilicate glass or stainless steel (steel quality to customer‘s specification); optional acrylic
piston: PE, PTFE, PVDF or stainless steel
seals: EPDM or Kalrez®
frits: PE, stainless steel, others on request

7. Pilot Columns - Sizes
columns from 60 mm to 600 mm ID
length on demand

8. Pilot Column - Design of Flow Distributor
flow distribution profile proofed by Bayer AG and Kronlab GmbH

9. Pilot Column - flexible inner diameters
PI 100 Cooling Jacket
PI 100
Flow distribution profile proofed by Bayer AG and Kronlab GmbH

10. Pilot Column - flexible column material
stainless steel
glass or acrylic

11. Pilot Column - flexible pressure ranges
50 bar
8,7 bar
10 bar
1 bar

12. Pilot Column - integration of user demands
e.g. rotable frames, integrated level indicator, brackets, selected materials, connectors ……….

13. Pilot Columns - Custom Design
special solutions for individual needs regarding:
materials
design
size
system integration

14. Pilot Columns - Custom Design
individual feasibility studies and technical drawings
certification
competent guidance throughout the whole project

15. Pilot AB - rotatable column id: 200 mm max. bed height: 1600 mm
pressure rating: 7 bar
specially designed rotatable frame construction

16. Pilot SR – solvent resistant
technical specifications:
column id: and 300 mm
max. bed height: 400 mm
pressure rating: 1.5 bar
explosion-proof environment with antistatic protection and wheels

17. Pilot SR – stainless steel
technical specifications:
column id: mm
max. bed height: 1000 mm
min bed height: 500 mm
pressure rating: 40 bar
sealing: Kalrez®

18. Pilot SR – stainless steel
technical specifications:
column id: mm
max. bed height: 900 mm
min bed height: 700 mm
pressure rating: 50 bar
sealing: Kalrez®

19. Pilot AB - Reactor id: 300 mm bed height: 0- 500 mm
pressure rating: 1 bar
frit: 30 µm
(SS )
special features:
slurry inlet
integrated magnetic stirrer on
cambered bottom frit
piston with scraper
special designed column stand

20. Pilot AB -rotatable id: 240 mm bed height: 0 - 270 mm volume: 0-12 l
pressure rating: 3 bar
cooling jacket: °C
SS - container: 15 l for slurry waste
frits: 10 µm PE 5 mm thickness specially designed frit fastening screws to ensure perfect flow distribution

21. Pilot Columns - stainless steel
id: mm
max. bed height: 1000 mm
(1500 mm)
bed volume: 282,6 l
(423,9 l)
pressure rating: 10 bar
frits: 10 µm

22. Pilot Column - stainless steel
Example
Pilot Column - stainless steel
id: mm
max. bed height: 1000 mm (1500 mm)
bed volume: 282,6 l (423,9 l)
pressure rating: 10 bar
frits: 10 µm
designed for repeated packing and unpacking without opening the column

23. Example Solvent Inlet Slurry-Inlet through separate slurry pump
Slurry-Outlet through central outlet valve
Solvent Outlets

24. Pilot Columns - References
Abbott
Aventis
Baxter Hyland Immuno AG
Bayer AG
Biotest
Clariant
Genetics Institute
Genzyme
Honeywell
Novartis AG
Schering AG
Roche Diagnostics
etc …