1. Diabetic Ketoacidosis at Diagnosis Influences Complete Remission After Treatment With Hematopoietic Stem Cell Transplantation in Adolescents With Type 1 Diabetes Featured Article: Weiqiong Gu, M.D., Jiong Hu, M.D., Ph.D., Weiqing Wang, M.D., Lirong Li, M.D., Wei Tang, M.D., Shouyue Sun, M.D., Weijuan Cui, M.D., Lei Ye, M.D., Ph.D, Yifei Zhang, M.D., Ph.D., Jie Hong, M.D., Ph.D., Dalong Zhu, M.D., Guang Ning, M.D., Ph.D. Diabetes Care Volume 35: 1413-1419 July, 2012

2. Study Objectives Gu W et al. Diabetes Care 2012;35:1413-1419 To determine whether autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was beneficial for type 1 diabetic adolescents with diabetic ketoacidosis (DKA) at diagnosis

3. Study Design Enrolled 28 patients with type 1 diabetes, aged 14–30 years, in a prospective AHSCT phase II clinical trial HSCs harvested from peripheral blood after pretreatment consisting of cyclophosphamide and antithymocyte globulin Changes in the exogenous insulin requirement and serum levels of HbA1c, C-peptide, and anti-glutamic acid decarboxylase antibody measured before and after the AHSCT Gu W et al. Diabetes Care 2012;35:1413-1419

8. Conclusions AHSCT appears to be an effective long-term treatment for insulin dependence that achieved a greater efficacy in patients without DKA at diagnosis Gu W et al. Diabetes Care 2012;35:1413-1419