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Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease by Françoise Bernaudin, Gérard Socie, Mathieu Kuentz,

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Presentation on theme: "Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease by Françoise Bernaudin, Gérard Socie, Mathieu Kuentz,"— Presentation transcript:

1 Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease by Françoise Bernaudin, Gérard Socie, Mathieu Kuentz, Sylvie Chevret, Michel Duval, Yves Bertrand, Jean-Pierre Vannier, Karima Yakouben, Isabelle Thuret, Pierre Bordigoni, Alain Fischer, Patrick Lutz, Jean-Louis Stephan, Nathalie Dhedin, Emmanuel Plouvier, Geneviève Margueritte, Dominique Bories, Suzanne Verlhac, Hélène Esperou, Lena Coic, Jean-Paul Vernant, and Eliane Gluckman Blood Volume 110(7):2749-2756 October 1, 2007 ©2007 by American Society of Hematology

2 Estimated outcomes: OS, EFS, and cumulative incidence of rejection in the 87 patients. Françoise Bernaudin et al. Blood 2007;110:2749-2756 ©2007 by American Society of Hematology

3 Comparison of the cumulative incidence of rejection in patients conditioned with and without antithymocyte globulin (ATG)-at 5 years 2.9% with ATG versus 22.6% without (P =.002). Françoise Bernaudin et al. Blood 2007;110:2749-2756 ©2007 by American Society of Hematology

4 Comparison of Kaplan-Meier estimates of EFS in patients receiving transplants before (n = 43) and after January 2000 (n = 44): respectively 76.7% and 95.3% at 5 years (P = 0.26). Françoise Bernaudin et al. Blood 2007;110:2749-2756 ©2007 by American Society of Hematology

5 Chimerism data. Françoise Bernaudin et al. Blood 2007;110:2749-2756 ©2007 by American Society of Hematology


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