1. Lecture VII. CNS Patterning Bio 3411 Wednesday September 22, 2010 1Lecture VII. CNS Patterning

2. Reading THE BRAIN ATLAS: p 10 2Lecture VII. CNS Patterning September 22, 2010

3. Lecture VII. CNS Patterning3 Selected References: † Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642. Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer. † Hartenstein, V. (1993). Atlas of Drosophila Development. Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division. Chapter 52, pp 1019-1040. † Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier. Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10 th ed.). Philadelphia,: Saunders. –––––––––––––– † (pdfs on course websites: [http://artsci.wustl.edu/~bio3411/] & [http://www.nslc.wustl.edu/courses/Bio3411/bio3411.html]

4. What the last Lecture was about General mechanisms for assembling neurons and groups of neurons Diffusion vs Contact Attraction vs Repulsion Examples of impacts of contact Examples of impacts of diffusion Specification by growth factors The chemoaffinity hypothesis September 22, 2010Lecture VII. CNS Patterning4

5. What this Lecture is about September 22, 2010Lecture VII. CNS Patterning5 The Initiation of the Central Nervous System CNS Growth and Pattern Development Bug Brains Several Mechanisms for Directing the Show (scripts conserved) How did vertebrate and invertebrate patterns arise?

6. September 22, 20106Lecture VII. CNS Patterning Recap of Early Embryogenesis

7. September 22, 20107Lecture VII. CNS Patterning Ranson & Clark (1959)

8. September 22, 20108Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

9. September 22, 20109Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

10. September 22, 201010Lecture VII. CNS Patterning From Tube to Brain

11. September 22, 201011Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

12. September 22, 2010Lecture VII. CNS Patterning12 THE BRAIN ATLAS 3 rd ed, p.10

13. September 22, 2010Lecture VII. CNS Patterning13 Hamilton, Boyd, & Mossman (1972)

14. September 22, 2010Lecture VII. CNS Patterning14 Hamilton, Boyd, & Mossman (1972)

15. September 22, 2010Lecture VII. CNS Patterning15 Hamilton, Boyd, & Mossman (1972)

16. September 22, 2010Lecture VII. CNS Patterning16 Hamilton, Boyd, & Mossman (1972)

17. September 22, 2010Lecture VII. CNS Patterning17 Hamilton, Boyd, & Mossman (1972)

18. September 22, 2010Lecture VII. CNS Patterning18 Hamilton, Boyd, & Mossman (1972)

19. September 22, 2010Lecture VII. CNS Patterning19 From Fly Egg to Fly Brain

20. September 22, 201020Lecture VII. CNS Patterning Hartenstein (1993)

21. September 22, 201021Lecture VII. CNS Patterning Hartenstein (1993)

22. September 22, 201022Lecture VII. CNS Patterning Hartenstein (1993)

23. September 22, 201023Lecture VII. CNS Patterning Hartenstein (1993)

24. September 22, 2010Lecture VII. CNS Patterning24 Segmentation and Signals

25. September 22, 201025Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

26. September 22, 201026Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

27. September 22, 201027Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

28. September 22, 201028Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

29. 29September 22, 2010Lecture VII. CNS Patterning Kandel, Schwartz, & Jessell (2000)

30. September 22, 2010Lecture VII. CNS Patterning30 Kandel, Schwartz, & Jessell (2000)

31. September 22, 201031Lecture VII. CNS Patterning Ancient Choice?

32. September 22, 2010Lecture VII. CNS Patterning32 Benito-Gutierrez & Arendt, (2009)

33. September 22, 201033Lecture VII. CNS Patterning Benito-Gutierrez & Arendt, (2009)

34. What this Lecture was about September 22, 2010Lecture VII. CNS Patterning34 The Initiation of the Central Nervous System CNS Growth and Pattern Development Bug Brains Several Mechanisms for Directing the Show (scripts conserved) How did vertebrate and invertebrate patterns arise?

35. Reflections Early events initiating the nervous system Beginning the sculpture – proliferation and death mechanisms Signals for functional and connectional specificity – contact, distance, for or against The pattern and organization emerges Generalizations made but questions unanswered September 22, 2010Lecture VII. CNS Patterning35

36. Sequential Restrictions (Refinements) are the Bases for Development (and plasticity) September 22, 201036Lecture VII. CNS Patterning pluripotent, stem cell differentiated genetic environmental

37. September 22, 2010Lecture VII. CNS Patterning37

38. September 22, 2010Lecture VII. CNS Patterning38 http://embryo.soad.umich.edu/

39. September 22, 2010Lecture VII. CNS Patterning39 Finis