1. 1 CPAC MBA Collaboration Project Matt Hallingstad  Ejike Anih  Siddharth Sureka mini-update 02.23.2011

2. 2 Background Inefficiencies at the CPAC: Sample collection from PIs Communication with PIs Data transfer Administrative laboratory management

3. 3 Recommendations Short term: Implement effective website communication Improve consultation form Hire Administrative Assistant Long term: Implement IT System to help manage the process

4. 4 Short Term Recommendations Implement effective website communication: Website improvements will clearly present CPAC’s value proposition and better manage PI expectations (incl. turn-around times). Website

5. 5 Sample Website Improvement IMPROVED: Quantification of Compounds; Development Of Quantification Methods CPAC performs quantification of drugs and metabolites with three state-of-the-art instruments: Applied Biosystems API 3200 LC/MS/MS; Applied Biosystems API 4000 LC/MS/MS; and Thermo Scientific HPLC/MS/MS. In addition to the HPLC/MS/MS’s, CPAC has access to HPLC systems equipped with UV, fluorescence, and other detectors that may be used for routine analyses. ORIGINAL: Access to state-of-the-art instrumentation for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The core has two of these instruments (HPLC-MS/MS; API 4000 and API 3200) for drug quantification. In addition to the two HPLC-MS/MS’s, the core facilities have access to additional HPLC systems (equipped with UV, fluorescent, or other detectors) that may be used for routine analyses.

6. 6 Short Term Recommendations Improve consultation form : The improved consultation form will capture key parameters required for efficient sample intake, and will convey information regarding expected turnaround times.

7. 7 Short Term Recommendations Hire Administrative Assistant: Part-time laboratory manager will facilitate intake of samples, coordinate communication with PIs, manage supplies and ordering, thereby allowing lab technicians to focus on core responsibilities.

8. 8 Long Term Recommendations Implement IT System to help manage the process: A comprehensive IT system will minimize process and operational inefficiencies by providing easy- to-use interface. It will also facilitate timely communication with PIs, reinforcing CPAC’s position as a state-of-the-art pharmacokinetic Core.