1. What happens when Meiosis Goes WRONG??

2. When homologous chromosomes fail to separate it is called “nondisjunction”
Abnormal # chromosomes will make their way into gametes
This may occur during Meiosis 1 or Meiosis 2
A fetus may be naturally aborted
A disorder may occur

3. Trisomy - three of the same number of chromosome

4. Down Syndrome
Trisomy 21
Three copies of the 21st chromosome
Mild to severe Mental Retardation
Increased susceptibility to many diseases and higher frequency of some birth defects

5. When something goes wrong with the division of the sex chromosome…..
Turners- only one X chromosome is inherited
Women are sterile, Sex organs don’t develop at puberty
Kleinefelter’s syndrome
XXY Kleinfelters small testes, man is sterile, female characteristics

6. Trisomy 18
Birth defects , increase in infant mortality, developmental delay
Trisomy 13
Small head, birth size, heart defects, vision and hearing problems, disabilities

7. Your Job… Create a Karyotype Determine the diagnosis
Downsyndrome, Klienfelters, or Turners Syndrome