1. Integrated Risk Analysis: the INTARESE IP David Briggs Department of Epidemiology and Public Health Imperial College London http://www.imperial-consultants.co.uk/intarese.org/home.htm

2. INTARESE  Integrated project (6 th FP)  5 year project  Started 1 st November 2005  Co-ordinator: Imperial College London  32 partners from 25 countries  Disciplines represented: epidemiology, toxicology, environmental science, geography, systems analysis, IT  User groups involved: WHO, national environmental and health agencies (France, UK), industry (CEFIC)

3. Rationale  Complex (multi-causal and multi-effect) environmental health problems  Need for preventative/precautionary approach – requires foresight and tracking  Need for integrated intervention (multiple benefits from single actions)  Need for comparative evaluation of risks  Need to target susceptible groups  Need to make best possible use of available data and knowledge

4. INTARESE: Aims To develop integrated approach to assessment and communication of risks from environmental stressors  Develop coherent framework for integrated risk analysis  Assess and develop information sources and analysis tools (environmental monitoring, biomonitoring, health surveillance, exposure assessment, consequence assessment, risk assessment)  Test and apply methodology to analyse range of contrasting policy areas (transport, agriculture, chemicals, wastes, climate, water resources, housing)  Develop assessment system (toolbox) for policy support

5. The structure of INTARESE SP7. Co-ordination and management SP 2 Monitoring and surveillance 2.1 Environmental monitoring 2.2 Biomonitoring 2.3 Health surveillance 2.4 Integrated monitoring SP 3 Policy assessments 3.1 Transport 3.2 Housing 3.3 Agricultural land use 3.4 Water 3.5 Chemicals in household products and articles 3.6 Waste 3.7 Climate SP1 Integrated assessment methods 1.1 Assessment framework 1.2 Source-exposure 1.3 Exposure-effect 1.4 Risk characterisation 1.5 Cross-cutting issues SP 6 User consultation and dissemination 6.1 User concerns and information needs 6.2 Dissemination SP 4 Integrated assessment system 4.1 Toolbox design 4.2 Toolbox development 4.3 Application and testing SP 5. Integration and training 5.1 Integration 5.2 Training

6. Integrated assessment: the INTARESE approach Analysis framework Source-exposure Exposure-effect Risk characterisation User needs Value systems Knowledge constraints Intake fraction Pathways/ propagation Exposure assessment Dose-response relationships Toxicity Expert assessment Impact assessment Cost-benefit Indicators