1. Lymphoid System
VIBS 443/602

2. OBJECTIVES PURPOSE OF THE IMMUNE SYSTEM CELLULAR BASIS OF IMMUNITY
EFFECTORS OF RESPONSE
INDUCTION OF THE RESPONSE
ONTOGENY

3. FUNCTIONS OF THE IMMUNE SYSTEM
PROTECTION AGAINST FOREIGN INVADERS INTO BODY
PRODUCE / PROTECT GERM FREE ENVIRONMENT OF THE BODY

5. Thymus

6. 123
Thymus, newborn

7. THYMUS
RETICULUM FRAMEWORK
- EPITHELIUM
EPITHELIUM

10. 116
Lymph node
Afferent
lymphatic
duct

11. Lymph node follicle
Germinal center
Lymphocyte
Reticulum cell

12. 116
Lymph node
Afferent
lymphatic
duct
Subscapular space

13. Parafollicular region
High endothelial cells of a venule
Parafollicular region

14. High endothelial cells of a venule
parafollicular region
High endothelial cells of a venule

15. INDUCTION OF RESPONSE
PERIPHERAL ORGAN NEEDED TO GET ANTIGEN AND RESPONSIVE CELL TO INTERACT
LYMPHOCYTE RECIRCULATING
APPROPRIATE CONTEXT

16. 19754 Lymphatic sinus in lymph node

17. Venous sinus Medullary cord Lymphatic sinus or Medullary sinus
Lymph node medulla:
Reticulum cell
Lymphocyte
Plasma cell
Medullary cord
Lymphatic sinus or
Medullary sinus

18. Lymphatic sinus or Medullary sinus
Macrophages in the lymph node medulla
Macrophages

19. Efferent lymphatic
duct?
116

20. Spleen

21. Spleen (reticulum stain)- capsule and reticulum fibers
218
Spleen (reticulum stain)- capsule and reticulum fibers

22. 122
Spleen

23. Spleen red and white pulp
122

24. Spleen:
Central artery
Periarteriolar lymphatic sheath
Red pulp

25. Spleen
122
Marginal zone

26. Spleen
122
central artery
PENICILLARY ARTERIES
Marginal zone

27. Splenic red pulp:
Venous sinus
Littoral cell
Billroth’s strand

28. Spleen reticulum:
Reticulum fiber
Billroth’s strand
Sinuses

29. Litteral cells of spleenic venial Spleen #19752 (UT117)

30. Tonsil

31. 419
Tonsil

32. Tonsil
419

33. Esophagus and trachea, monkey
242
Esophagus and trachea, monkey

34. 145
Fundic stomach

35. Large intestine or Colon, monkey
153
Large intestine or Colon, monkey

36. Plasma cells large intestine in Colon, monkey
153
Plasma cells large intestine in Colon, monkey

37. 32412

38. EM 6

39. Image
112

40. LIFE CYCLE OF LYMPHOCYTES
FETAL ORGANS
BONE MARROW
PRIMARY LYMPHOID ORGANS
(ANTIGEN INDEPENDENT DEVELOPMENT)
- THYMUS - T LYMPHOCYTES
- BONE MARROW - B LYMPHOCYTES
SECONDARY LYMPHOID ORGANS
(ANTIGEN DEPENDENT DEVELOPMENT)
LYMPH NODES
LYMPHOID NODULES
SPLEEN

41. ONTOGENY STEM CELLS - BONE MARROW PRIMARY LYMPHOID ORGANS
SECONDARY LYMPHOID ORGANS
DIFFERENTIATION
TO MATURE
ANTIGEN –
REACTIVE CELLS

42. thymus
Bone marrow