1. Gross Anatomy of Skeletal Muscle
Muscle fiber
Endomysium
Fascicle
Perimysium
Epimysium
Deep facia

2. Connective Tissue Sheaths
Endomysium
Perimysium
Epimysium
Collagen fibers of all 3 layers come together at each end of muscle to form a tendon or aponeurosis.

3. Microscopic Muscle Fiber Anatomy
Sarcolemma - ‘cell membrane’
Sarcoplasm - ‘cytoplasm’
Myoglobin**
Transverse tubules
Sarcoplasmic
Reticulum
Myofibrils
A band
I band

4. Myofibril Myofilaments Two types
Actin (+ 2) filaments (thin filaments)
Myosin filaments (thick filaments)

5. Sarcomere Between 2 Z-discs Contractile Unit
Sarcomere + sarcomere + sarcomere = myofibril
A band

6. I bands

7. Z lines
Sarcomere

8. Actin and Myosin Filaments

9. Myosin (Thick) Filament
1 protein
Generates tension

10. Actin (Thin) Filament Three proteins Actin (contractile)
Troponin (lock)
Tropomyosin (door)

11. axon
T tubules
myofibrils
sarcomere
plasma membrane