1. NSAIDs: Risk of acute MI compared with remote use Largest NSAID database study ever casts doubt on entire coxib controvers [Rheumawire > News; Jun 10, 2005] Singh G, et al. EULAR 2005; June 8-11, 2005; Vienna, Austria. NSAIDUnadjusted odds ratio Adjusted odds ratio 95% CIp Indomethacin1.651.711.35-2.17<0.0001 Sulindac1.461.411.01-1.960.04 Meloxicam1.341.371.05-1.780.02 Rofecoxib1.341.321.22-1.42<0.0001 Piroxicam1.141.180.90-1.540.22 Other NSAIDs1.221.180.94-1.460.15

2. NSAIDs: Risk of acute MI compared with remote use Largest NSAID database study ever casts doubt on entire coxib controvers [Rheumawire > News; Jun 10, 2005] Singh G, et al. EULAR 2005; June 8-11, 2005; Vienna, Austria. NSAIDUnadjusted odds ratio Adjusted odds ratio 95% CIp Ibuprofen1.081.111.01-1.220.02 Celecoxib1.111.091.02-1.150.008 Naproxen1.031.080.95-1.220.22 Diclofenac1.041.050.93-1.190.43 Valdecoxib1.080.990.72-1.370.97 Ketoprofen0.880.860.63-1.180.35 Nabumetone0.860.830.60-1.140.26

3. NSAID use in cohort study Singh G, et al. EULAR 2005; June 8-11, 2005; Vienna, Austria. Largest NSAID database study ever casts doubt on entire coxib controvers [Rheumawire > News; Jun 10, 2005] Drug usePatientsPatient- years Percentage of cohort Celecoxib299 550220 20146.04 Diclofenac109 40244 48816.82 Ibuprofen371 051109 66657.03 Indomethacin40 16892666.17 Ketoprofen18 57575772.86 Meloxicam26 12384134.02 Nabumetone25 28683683.89 Naproxen172 29551 64526.48

4. NSAID use in cohort study Singh G, et al. EULAR 2005; June 8-11, 2005; Vienna, Austria. Largest NSAID database study ever casts doubt on entire coxib controvers [Rheumawire > News; Jun 10, 2005] Drug usePatientsPatient-yearsPercentage of cohort Other NSAIDs90 53932 83213.92 Piroxicam22 21292433.41 Rofecoxib209 974112 76032.27 Sulindac15 90660872.44 Valdecoxib26 52661614.08 Total650 5902 356 884.5 Aspirin203 233241 81631.24