1. Purvi Mehta, MS; Manoj Sharma Ph.D., MCHES; Anders Cedergren MS, CHES

2. (1)The following personal financial relationships with commercial interests relevant to this presentation existed during the past 12 months: Purvi Mehta “No relationships to disclose”

3.  Virus attacking skin and mucous membranes  100’s but about 30 spread through sexual contact HPV 6, 11, 16 and 18 of prime interest  Affects genital areas – vulva, vagina, cervix, rectum, anus, penis, and scrotum  Genital warts, intraepithelial neoplasia and cancers (cervical)  2 classifications: High risk (cervical cancer) : 6, 11 low risk (genital warts): 16, 18

4.  Also known to cause: Warts, including common warts (verrucae vulgaris), plantar warts (verrucae plantaris), and flat warts (verrucae plana) Precancerous lesions, including on the cervix (high- grade dysplasia and low-grade dysplasia) Other precancerous lesions or cancer, including on the penis, anus, vagina, and vulva Laryngeal papillomas, which are noncancerous tumors on the larynx (voice box), vocal cords, or the air passages leading from the nose into the lungs (respiratory tract).

5. 6.2 million people are newly diagnosed 20 million currently are diagnosed 40-50% of cases are found in women between 14 to 24 years old Limited data is available regarding incidence and prevalence rates of HPV About 50% of men that are sexually active acquire HPV in their lifetime

6. 51.1% of men tended to carry multiple strains of HPV Approximately 73% of men have been infected with HPV Led to approximately 93% of anal cancers, 63% oropharyngeal cancers, and 36% of penile cancers. Gay and bisexual men are more likely to be diagnosed with HPV Prevalence of HPV is 60% in men without HIV, and close to 90% in those with HIV 17 times more likely to develop anal cancer Detection of HPV DNA under fingernail tips to be common in men There are no methods to test for HPV

7. Gardasil, is an approved vaccine that helps guard against 90% of genital warts in males Three shots over the course of three months Must be between 9-26 years of age Best before sexual debut

8. Perceived susceptibility is the belief the person may acquire HPV Perceived severity is that HPV is a serious disease with negative consequences Perceived benefits are the belief in the advantages of suggested prevention methods namely HPV vaccine. Perceived barriers are things such as costs and side effects that would prevent them from taking the vaccine Cues to action are factors that will motivate individuals to take the vaccine Self-efficacy in taking the HPV vaccine is the confidence that a person has in her or her ability to take the HPV vaccine.

9. A relationship between vaccine acceptability and males that believed sexual partners, parents or physicians would encourage taking the vaccine, having a firm belief in the general importance of the vaccine, knowledge and awareness of HPV, perception of being at high risk, and belief in vaccinations

10. The purpose of the study is to determine the role of the health belief model in predicting HPV vaccine acceptability among gay and bisexual men

11. A cross-sectional study A valid and reliable survey based on the health belief model (HBM) was developed by the researcher and faculty mentor Table 1. Reliability Coefficients (Cronbach’s alpha) for Perceived Susceptibility, Perceived Severity, Perceived Benefits, Perceived Barriers, Cues to Action, Self Efficacy and Knowledge ______________________________________________________________________________ Constructs Alpha levels ______________________________________________________________________________ Perceived Susceptibility 0.900 Perceived Severity 0.753 Perceived Benefits 0.585 Perceived Barriers 0.920 Cues to Action 0.706 Self Efficacy 0.761 Knowledge 0.705

12. Test-retest Reliability Coefficients for Perceived Susceptibility, Perceived Severity, Perceived Benefits, Perceived Barriers, Cues to Action, Self Efficacy and Knowledge ______________________________________________________________ Constructrp-value _______________________________________________________________ Perceived Susceptibility.819.003 Perceived Severity.603.006 Perceived Barriers.853.000 Perceived Benefits.652.050 Cues to Action.571.009 Self Efficacy.647.002 Knowledge.624.003

13. Participants: Males, homosexual or bisexual, 18 years or older, attending the University of Cincinnati Approval from the IRB of the University of Cincinnati was obtained prior to study. Administration of the survey was conducted at the end of class time. Clipboards and pens were provided for completion of the survey. Participants were asked to complete the survey to their best ability. Anonymity of responses were assured to them. Once surveys were completed, participants slid the surveys into a manila envelope.

14. All data were analyzed in PASW (Predictive Analytics SoftWare), formerly SPSS, Version 18. Descriptive statistics, along with stepwise multiple regression were conducted to determine what factors affect vaccine acceptability Health belief model construct variables served as independent variables and whether participants would take the vaccine was the dependent variable. Alpha levels were set to 0.5 to determine significance

15. Summary of the Demographic Characteristics of homosexual and bisexual men ____________________________________________________ Variablen MinimumMaximum Mean St. Deviation ________________________________________________ Age (in years) 87 18 26 20.28 3.42 Year in College 87 1 52.25 1.09 Marital Status 87 0 1 0.02 0.15

16. Summary of the Demographic Characteristics of homosexual and bisexual men ______________________________________________________________________ VariableFrequency Percent Valid percentCumulative percent ______________________________________________________________ Yes 31 35.6 35.6 35.6 Maybe 37 42.5 42.5 78.2 No 19 21.8 21.8 100.0 Total 87 100 100

18. Parameter Estimates from the Final Regression Model for Self Efficacy and Cues to Action (R 2 = 0.421) _________________________________________________________________________ Source Unstd. Coeff. Std. Error Std. Coefficients Beta t p-value _________________________________________________________________________ (constant) 3.926 0.266 14.486 0.000 Self Efficacy -0.160 0.026 -0.547 - 6.268 0.000 Cues to Action -0.042 0.017 -0.218 -2.501 0.014

19. Self-efficacy and cues to action were able to explain some variance in whether males would take the HPV vaccine Negative relationships were seen among the independent variable and the dependent variable Results were based on a self-report survey, which could have included both participant bias and dishonesty Recruiting participants was difficult, leading to a low sample size and the continuous recruitment of more participants a need for an intervention to increase vaccine acceptability

20. Based on preliminary results Self-report Cross-sectional study Location Conducted in a University setting only, results and sample size may have been different if recruitment was expanded to outside the university system