3. Components of Blood Whole blood –RBCs –WBCs –Platelets: cell fragments that aid in clotting Plasma –90% water (allows materials to dissolve) –Amino acids, glucose, hormones, vitamins, salts, waste –Concentrations allows diffusion in/out of blood stream

4. Click picture to play

5. Red Blood Cells Produced from stem cells in bone marrow Lose nucleus as they mature Transport O2 to cells; remove CO2 O2 binds to hemoglobin proteins Dead cells filtered by liver & spleen

6. NormalSickle Cell

7. White Blood Cells Remove foreign invaders & dead cells Able to move through body tissue

8. Platelets Form clots when bleeding Proteins form a web to trap cells & platelets

9. Proteins on blood cells determine blood type Antigen (markers) –proteins on cell’s surface that identify cells as foreign or natural Antibodies: –proteins from B cells to attack invaders –Float freely in plasma ABO Blood Groups

10. Group A blood A antigens on the surface of your RBCs B antibodies in your blood plasma

11. Group B blood B antigens on the surface of your RBCs A antibodies in your blood plasma

12. Group AB blood Both A and B antigens on the surface of your RBCs Neither A or B antibodies in your blood plasma

13. Group O blood Neither A or B antigens on the surface of your RBCs Both A and B antibodies in your blood plasma

14. If you have type A blood, can you receive: Type B blood from a donor? Type AB blood from a donor? Type O blood from a donor?

15. If you have type B blood, can you receive: Type A blood from a donor? Type AB blood from a donor? Type O blood from a donor?

16. If you have type AB blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type O blood from a donor?

17. If you have type O blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type AB blood from a donor?

20. Rh Factors If Rh+ –Protein found in blood –Can receive Rh+ or Rh- blood If Rh- –Lack protein in blood –Only receive Rh- blood

21. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

22. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

23. Vein This person has B+ blood type because of the B and Rh antigens Can he accept B+ blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur.

24. Vein This person has B+ blood type because of the B and Rh antigens Can he accept B- blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens B- B antigens B- B antigens B- B antigens Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur.

25. Vein This person has B+ blood type because of the B and Rh antigens Can he accept A+ blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens A+ A antigens Rh antigens A+ A antigens Rh antigens A+ A antigens Rh antigens No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die.

26. Vein This person has B+ blood type because of the B and Rh antigens Can he accept A- blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens A- A antigens A- A antigens A- A antigens No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die.

27. Vein This person has B+ blood type because of the B and Rh antigens Can he accept AB+ blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die.

28. Vein This person has B+ blood type because of the B and Rh antigens Can he accept AB- blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens AB- A antigens B antigens AB- A antigens B antigens AB- A antigens B antigens No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die.

29. Vein This person has B+ blood type because of the B and Rh antigens Can he accept O+ blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens O+ Rh antigens O+ Rh antigens O+ Rh antigens Yes. The A antibodies won’t attack. Therefore, no clumping of blood cells will occur.

30. Vein This person has B+ blood type because of the B and Rh antigens Can he accept O- blood? A antibody B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens O- No antigens O- No antigens O- No antigens Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur.

31. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

32. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

33. This person has A- blood type because of the A antigen Can he accept A- blood? B antibody Rh antibody A- A antigens Yes. The B and Rh antibodies will not attack. Therefore, no clumping of blood cells will occur. Rh antibody A- A antigens A- A antigens A- A antigens A- A antigens A- A antigens

34. This person has A- blood type because of the A antigen Can he accept A+ blood? B antibody Rh antibody A+ A antigens Rh antigens No. The Rh antibodies will attack the Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A+ A antigens Rh antigens A+ A antigens Rh antigens A- A antigens A- A antigens A- A antigens Rh antibody

35. This person has A- blood type because of the A antigen Can he accept B- blood? B antibody Rh antibody B- B antigens No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. B- B antigens B- B antigens A- A antigens A- A antigens A- A antigens Rh antibody

36. This person has A- blood type because of the A antigen Can he accept B+ blood? B antibody Rh antibody B+ B antigens Rh antigens No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. B+ B antigens Rh antigens B+ B antigens Rh antigens A- A antigens A- A antigens A- A antigens Rh antibody

37. This person has A- blood type because of the A antigen Can he accept AB- blood? B antibody Rh antibody AB- A antigens B antigen No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. AB- A antigens B antigen AB- A antigens B antigen A- A antigens A- A antigens A- A antigens Rh antibody

38. This person has A- blood type because of the A antigen Can he accept AB+ blood? B antibody Rh antibody AB+ A antigens B antigens Rh antigens No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Rh antibody AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens A- A antigens A- A antigens A- A antigens

39. This person has A- blood type because of the A antigen Can he accept O- blood? B antibody Rh antibody O- No antigens Yes. The antibodies will not attack. Therefore, no clumping of blood cells will occur. Rh antibody O- No antigens O- No antigens A- A antigens A- A antigens A- A antigens

40. This person has A- blood type because of the A antigen Can he accept O+ blood? B antibody Rh antibody O+ Rh antigens Yes. The antibodies will not attack. Therefore, no clumping of blood cells will occur. Rh antibody O+ Rh antigens O+ Rh antigens A- A antigens A- A antigens A- A antigens

41. Blood type AB+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

42. Blood type O+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

43. Blood type AB- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

44. Blood type B+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

45. Blood type O- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

46. Can this work? Acceptor 1. O- 2. A+ 3. AB- Donor 1.AB- 2. A- 3. B-

47. 1) Can this work? Acceptor O- Donor AB-

48. 2) Can this work? Acceptor A+ Donor A-

49. 3) Can this work? Acceptor AB- Donor B-

50. Quiz 1)What are the components found inside blood? 2)What are the ingredients of plasma? 3)What is the purpose/function of RBCs? 4)Which part of blood stop bleeding when cut? 5)What do antibodies bind with? 6)If a person has type AB-, which antigens do they possess? Which antibodies? 7)If a person has type O+, which antigens do they possess? Which antibodies? 8)If a person is type A-, list all the blood types this person can receive in a transfusion. 9)If a person is type O-, list all the blood types this person can receive in a transfusion.