1. WP1 Justification & Guideline Development Keith Horner

2. Work package 1 objectives: 1. to perform a systematic review of CBCT based on ‘dose and risk’, ‘diagnostic accuracy’ and ‘quality assurance’ 2. to develop provisional guidelines to input into WP6. 3. to incorporate knowledge obtained from the results of SEDENTEXCT study 4. to develop definitive referral criteria and guidelines on quality assurance, optimization etc. to input into WP6.

3. Objectives for Year 2: Due DateStatus D1.1 (M1.4) Systematic review complete 31 Jan 2009*Completed M1.5 Second Guideline Development Panel (GDP) meeting 31 Mar 2009*Completed 12/13 March 2009 D1.2 Provisional guidelines developed 31 Mar 2009*Completed 6 April 2009 * Deferred deadlines agreed with EC through Annual Report process

4. Scientific Progress Report: Systematic Review process

5. Scientific Progress Report: Systematic Review process Critical appraisal using standard forms

6. Scientific Progress Report: Guideline development process: evidence tables

7. Scientific Progress Report: Guideline development Panel meeting (March 2009) Each topic addressed by two assessors Asked to consider evidence tables and formulate recommendations, taking into account: Volume of evidence Applicability of the findings to clinical practice Generalisibility of the results presented to the guideline’s target population Consistency of the results (highlighting any major inconsistencies) Clinical impact (e.g resource implications, balance of risk/benefit)

8. Scientific Progress Report: Provisional Guideline document Internal/ external review pre- release (v1.0) Feedback after release of v1.1 Dissemination

9. Scientific Progress Report: Systematic Review process: problems encountered Some allocation of studies into wrong categories Some papers for review fitted several categories, not just one. The review form design for “diagnostic accuracy” studies could have been better

10. Forward Planning: Start earlier

11. Forward Planning: Finalise the revised proformas for systematic review and data extraction (UNIMAN/MAHOD) Set up intranet pages for posting of papers for review (UNIMAN) Analyse feedback on Provisional Guidelines document (UNIMAN) Continue with literature searches and collection of national guideline documentation (UNIMAN) Confirmation of membership of Guideline Development Panel (all partners except LTO)

12. Diagnostic accuracy or “Studies of diagnostic relevance”

13. Protocol 1

15. Protocol 2

18. Forward Planning: