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1 Kidney Transplantation Committee Spring 2016
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2 Recent Public Comment Proposals OPTN Kidney Paired Donation (KPD) Priority Points Changes apply only to the OPTN KPD program Revisions to priority points (e.g. sliding scale for CPRA and donor/candidate blood type) Remedy for candidates in a failed exchange Board Approved: Dec. 2015 Implementation: Pending Programming
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3 Policy Implementation Dates OPTN KPD Deadlines and Message Boards Changes apply only to the OPTN KPD program Programs deadlines for: Match offer preliminary responses Performing crossmatches Providing and reviewing donor records Total time from offer to final acceptance/refusal = 15 business days Creates message boards for communication Board Approved: June 2015 Estimated Implementation: Within 1 st half of 2016
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4 KAS Update Spring 2016
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KAS implemented Dec 4, 2014 Key goals: Make better use of available kidneys Increase transplant opportunities for difficult-to-match patients (increased equity) Increase fairness by awarding waiting time points based on dialysis start date Have minimal impact on most candidates Background
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Performance tracked monthly for first six months (“out of the gate” reports) Comprehensive, 6-month analysis provided to the kidney committee in Sep 2015 One year analysis requested by the committee (analyses underway) Pre-KAS period: Dec 4, 2013 – Dec 3, 2014 (12 months) Post-KAS period: Dec 4, 2014 – Dec 3, 2015 (12 months) Solitary, deceased donor kidney transplants This slide set contains highlights from the full one-year report Background
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Trends in kidneys recovered and transplanted ↑ 4.6% ↑ 6.2% Kidneys recovered for transplant Solitary kidney transplants Nearly 1,000 more deceased donor kidneys were recovered post- KAS, and nearly 500 more transplants occurred.
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Who’s getting transplanted under KAS? Percentage of Deceased Donor Kidney Transplants by Recipient Age More young candidates (18-49) are receiving kidney transplants. Transplants to pediatrics rebounded in 2 nd six months
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Who’s getting transplanted under KAS? Percentage of Deceased Donor Kidney Transplants by Recipient Race/ethnicity More African Americans are receiving kidney transplants, although less so during the 2 nd six months.
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Who’s getting transplanted under KAS? Percentage of Deceased Donor Kidney Transplants by Recipient Blood Type The distribution of transplants has changed little by recipient ABO. Slight increases for blood type B and AB patients.
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Who’s getting transplanted under KAS? Percentage of Deceased Donor Kidney Transplants by Recipient CPRA Transplants increased sharply for CPRA 99-100% patients but have tapered during the 2 nd six months.
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Who’s getting transplanted under KAS? Percentage of Deceased Donor Kidney Transplants by Recipient Duration on Dialysis More transplants are going to long dialysis duration recipients. Fewer preemptive (before dialysis) transplants.
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Geographic distribution of kidney transplants More kidneys are being distributed outside recovery OPO’s DSA. CIT>24 hours: Pre-KAS 18.2%, Post-KAS 21.6%. 21.4% 31.5%
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Geographic distribution of kidney transplants The distribution of transplants by OPTN region has changed little.
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Kidney recovery under KAS The distribution of recovered kidneys by KDPI has remained very similar. Percentage of Recovered Deceased Kidney Donors by KDPI
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Kidney recovery & utilization under KAS Discard rates initially rose during 1 st six months... Kidney Discard Rate by KDPI
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Kidney recovery & utilization under KAS ... but subsequently stabilized. Further tracking and study underway. Kidney Discard Rate by KDPI
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0 ABDR mismatches declined from 8.2% to 4.7% of transplants 22% fewer transplants with 30+ year donor/recipient age difference Delayed graft function (DGF) rates increased from 24% to 30%. Six month graft survival rates* remain statistically unchanged (p=0.13) Pre-KAS: 95.8% Post-KAS: 95.2% Other findings * Based on the first 4 months of post-KAS transplants
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Overall – KAS is meeting key goals Increase highly sensitized recipients; tapering effect observed Increase in access for African Americans and high dialysis time recipients, also with tapering observed Fewer longevity mismatches Transplant volume is up nearly 5% Several effects deserve further attention: Logistical challenges in allocation, increased CIT Discard rates Increased DGF; early graft survival rates statistically unchanged (but small N) Summary: First Year of KAS
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Mark Aeder, MD Committee Chair Mark.Aeder@uhhospitals.org Melinda Woodbury Committee Liaison Melinda.Woodbury@unos.org Questions? 20
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