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The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,

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Presentation on theme: "The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux,"— Presentation transcript:

1 The Effect of Recombinant Human Bone Morphogenetic Protein-2 in Single-Level Posterior Lumbar Interbody Arthrodesis by J. Michielsen, J. Sys, A. Rigaux, and C. Bertrand J Bone Joint Surg Am Volume 95(10):873-880 May 15, 2013 ©2013 by The Journal of Bone and Joint Surgery, Inc.

2 The CONSORT (Consolidated Standards of Reporting Trials) diagram. J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

3 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

4 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

5 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

6 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

7 The difference between the groups with respect to the mean score (and standard deviation) for bone density on the CT scan at three, six, and twelve months (p = 0.002, p = 0.024, and p = 0.014, respectively). J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

8 Difference between the groups with respect to the mean score (and standard deviation) for interbody healing on the BTB (bridging trabecular bone) scale at three, six, and twelve months (p = 0.021, p = 0.004, p = 0.014). J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

9 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

10 J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

11 A CT scan (sagittal and horizontal reconstruction) of the fused segment in a patient who received rh-BMP-2, showing resorption of the posterior aspect of the end plates at three months and ectopic bone and cyst formation posterior to the cages at twelve mon... J. Michielsen et al. J Bone Joint Surg Am 2013;95:873-880 ©2013 by The Journal of Bone and Joint Surgery, Inc.

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