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Exam #1 W 2/11 at 7:30-9pm in BUR 106 Bonus posted
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Phenotype Genotype Fig 13.5
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The inheritance of genes on different chromo- somes is independent.
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Y y rR Gene for seed color Gene for seed shape Approximate position of seed color and shape genes in peas Chrom. 1/7Chrom. 7/7 Fig 13.8
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The inheritance of genes on different chromosomes is independent: independent assortment
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Fig 13.8 meiosis I meiosis II
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Fig 13.8 The inheritance of genes on different chromosomes is independent: independent assortment
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Fig 13.5
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Inheritance can be predicted by probability
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Probability of a 4= 1/6 Probability of two 4’s in a row= 1/6x1/6=1/36
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Probability of 3 or 4 = 1/6+1/6= 1/3
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“and” multiply “or” add
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Huntington’s Disease D=disease d=normal Neurological disease, symptoms begin around 40 years old.
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Mom = ddDad = Dd d or d D or d Dd dd possible offspring 50% Huntington’s 50% Normal Mom Dad Huntington’s Disease D=disease d=normal
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Two different people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? (Dd hh)
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Two people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? Dd hh Probability of each outcome: Probability of Dd (Ddxdd) =.5 Probability of hh (HhxHh) =.25
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Two people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? Dd hh Probability of each outcome: Probability of Dd (Ddxdd) =.5 Probability of hh (HhxHh) =.25 Multiply both probabilities.25 X.5 = 12.5% chance Dd hh offspring
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Tracking two separate genes, for two separate traits, each with two alleles. Ratio of 9:3:3:1 Fig 13.5
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Some crosses do not give the expected results Fig 13.13
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CB 15.5 Heterozygous wild type gray w/ normal wings b + b vg + vg Homozygous wild type black w/vestigial wings b b vg vg
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=25% 8%9%41%42% Fig 13.13
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Does this show recombination? D/d M1/M2 d/d M1/M2 D/d M1/M2 d/d M2/M2 D/d M2/M2 d/d M2/M2
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Does this show recombination? D/d M1/M2 d/d M1/M2 D/d M1/M2 d/d M2/M2 D/d M2/M2 d/d M2/M2 arentalecomb.
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=25% 8%9%41%42% Fig 13.13 Why fewer recombinants than parentals?
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These two genes are on the same chromosome Fig 13.14
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These two genes are on the same chromosome, and close together. Fig 13.14
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Homologous pair of chromosomes Fig 13.15
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Fig 13.13
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By comparing recombination frequencies, a linkage map can be constructed = ? m.u.
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By comparing recombination frequencies, a linkage map can be constructed = 17 m.u.
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Linkage map of Drosophila chromosome 2 Fig 13.16
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Only 2 of the 4 chromosomes can cross-over. Fig 13.14 Recombinants
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Linkage map of Drosophila chromosome 2 Fig 13.16
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Yeast chromosome 3 physical distance linkage map Recombination is not completely random.
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Fig 13.19 A single gene with 2 alleles only has a few phenotypes Traits coded for by multiple genes have a variety of phenotypes Height of males at Conn. Ag. College in 1914
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Wheat color shows wide variation... Fig 13.20
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...and is coded for by three genes. Fig 13.20
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Exam #1 W 2/11 at 7:30-9pm in BUR 106 Bonus posted
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