1. Genetic Disorders Caused by ___?________ in the DNA mutations

2. Recessive Disorders Cause of most genetic disorders 2 recessive alleles: 1 from mom and 1 from dad

3. Autosomal Recessive Disorders Example: Sickle Cell Anemia Most common blood disorder Usually affects those of African decent – Deformed “sickled” red blood cells – What problem will that cause? What do blood cells carry? Ryan Clark

4. https://www.youtube.com/watch?v=K hLdthi89mU Example: Sickle Cell Anemia Most common blood disorder Usually affects those of African decent – Deformed “sickled” red blood cells – What are some problems that could stem from this?

5. Practice-autosomal recessive Show the results of a cross between two individuals heterozygous for Sickle Cell Disease. (S-normal s-disease) What is the percent chance that the offspring will have sickle cell?

6. Example If both parents are heterozygous (Ss)…….

7. Practice-autosomal recessive Show the results of a cross between one heterozygous and one individual who has Sickle Cell Disease. (S-normal s-disease) What is the percent chance that the offspring will have sickle cell?

8. Autosomal Recessive Disorders Cystic Fibrosis Abnormal transport o of chloride and sodium = thick mucus secretions = terrible cough Most common in Caucasians of European decent

9. Autosomal Dominant Autosome: all body cells (not sex cells) Dominant: strong allele/big letters Must inherit 1 dominant allele: 1 from mom or 1 from dad to end up with the genetic disorders

10. Autosomal Dominant Huntington’s Disease – Damages nerve cells Marfran Syndrome – Mutation causes a problem with the connective tissue in the body

12. Practice-autosomal dominant Show the results of a cross between two individuals heterozygous for Huntington’s Disease. (H-disease, h-normal) What is the percent chance that the offspring will have Huntington’s Disease?

13. Sex-linked traits Female XX Male XY

14. Sex Determination X chromosome carries genes (longer chromosome) Y does NOT carry many genes (shorter chromosome) Females get 2 X chromosomes so they have a 50%/50% of getting the disorder Males get 1 X chromosome from mom so if the chromosome is present on that X then the child has the disorder

15. http://dnalc.org/view/16263- Animation-10-Chromosomes-carry- genes-.html

16. Sex Linked traits-Colorblind The gene for colorblindness is carried on the X-chromosome. C- normal; c-colorblind Mother: X C X c Father: X c Y

18. Sex Determination Questions 1.How is sex linked inheritance from autosomal inheritance? 2. Why are more males colorblind than females?

19. Genetic Disorders Packet #1-10 completed by Thursday 3/19