1. NSCI 324* Systems Neuroscience Doug Munoz Centre for Neuroscience Studies Botterell Hall, room 226 x32111 doug.munoz@queensu.ca Tutorial: Monday Jan 23, 2012 10:30am Botterell B147 TA: Jay Jantz (j.jantz@queensu.ca)

2. NSCI 324* Systems Neuroscience Vision and Oculomotor Control (Dr. Munoz) January 10The retina January 13Central Visual Pathways January 16Dr. Munoz Tutorial: January 16Higher Visual functions January 17Oculomotor System I. Basic organization January 20 Oculomotor System II. Vestibulo-ocular reflex January 23Dr. Munoz tutorial: January 23Oculomotor System III. Saccades January 24Basal Ganglia for cognitive and motor control January 27review of Dr. Munoz lecture material January 30Dr. Munoz exam in tutorial period

3. Oculomotor system II. VOR (vestibulo-ocular reflex)

4. Properties of Motoneurons Firing Frequency Eye Position (E) Firing Frequency Eye Velocity (E)

5. Extraocular Muscle Motoneurons ­carry eye position and eye velocity ­final common path for all eye movements ­integrator located in reticular formation and vestibular complex of brainstem ­part of final common path ­“Neural integrator” integrates E command to produce E command muscle MN E + E E + E +

6. Vestibulo-ocular Reflex

7. Vestibulo-Ocular Reflex CNS H E H (-1) = E

8. Semicircular canals 3 semicircular canals (horizontal, anterior, posterior) on each side of head The canals are orthogonal to each other to represent complete 3-d rotations

10. Vestibulo-ocular Reflex

11. Head motion nose LR MR LR MR Horizontal canal Vestibular Nucleus Abducens Nucleus Oculomotor Nucleus LR = lateral rectus MR = medial rectus midline (midbrain)(pons)(pons-medulla) Horizontal VOR

12. Vestibular hair cell and afferent response Hair cell (generator potential) Primary vestibular afferent (action potentials to cns via 8 th nerve) Opponent processing: afferent has resting discharge and can therefore signal both directions of head motion via increase or decrease in activity

13. Head motion nose LR MR LR MR Horizontal canal Vestibular Nucleus Abducens Nucleus Oculomotor Nucleus LR = lateral rectus MR = medial rectus midline (midbrain)(pons)(pons-medulla) (-) Horizontal VOR

14. Head motion nose LR MR LR MR Horizontal canal Vestibular Nucleus Abducens Nucleus Oculomotor Nucleus LR = lateral rectus MR = medial rectus midline (midbrain)(pons)(pons-medulla) Horizontal VOR

15. Head motion nose LR MR LR MR Horizontal canal Vestibular Nucleus Abducens Nucleus Oculomotor Nucleus LR = lateral rectus MR = medial rectus midline (midbrain)(pons)(pons-medulla) Horizontal VOR

16. Vestibulo-ocular Reflex

17. Canals organized into 3 orthogonal planes Muscles organized into 3 orthogonal pairs 3-D organization of VOR