1. Vaccination game

2. 32 Vaccinated 32 Susceptible Vaccination game

3. 32 Vaccinated 32 Susceptible Vaccination game

4. Vaccinated Susceptible Infected N S EW

5. Remove to create first case Vaccinated Susceptible Infected N S EW 1

6. N S EW Remove to create first case Infect susceptible neighbours Vaccinated Susceptible Infected 1

7. N S EW Remove to create first case Infect susceptible neighbours Repeat until epidemic over Vaccinated Susceptible Infected 1 2 2

8. N S EW Remove to create first case Infect susceptible neighbours Repeat until epidemic over Vaccinated Susceptible Infected 1 2 2 3 3 3

9. N S EW Remove to create first case Infect susceptible neighbours Repeat until epidemic over Vaccinated Susceptible Infected 1 2 2 3 3 3 4 4 4 4

10. N S EW Remove to create first case Infect susceptible neighbours Repeat until epidemic over Record total cases Vaccinated Susceptible Infected

11. N S EW Remove to create first case Infect susceptible neighbours Repeat until epidemic over Record total cases Try with 48 vaccinated/16 not Vaccinated Susceptible Infected

12. R 0 measures how quickly an epidemic will take off… R 0 < 1 Cases decrease each step R 0 > 1 Cases increase each step Reproduction number ( R 0 ) ?

13. Herd immunity

14. Proportion of the population we need to vaccinate: Herd immunity R0R0 R 0 -1 Rabies0 Flu1–2 Ebola (West Africa)1–2 Chickenpox10 Measles16–18

15. Proportion of the population we need to vaccinate: Herd immunity R0R0 R 0 -1 R 0 Vaccinate Flu1–21/2 Ebola (West Africa)1–21/2 Chickenpox109/10 Measles16–1817/18