1. A. B. Supplemental Figure S1

2. A. B. Supplemental Figure S2

3. Supplemental Figure S3

4. Supplementary Figure S4 A.B.C.

5. A. Colon26 B. Tubo.A5 Supplemental Figure S5

6. C. A. Serum drug levels (ug/ml) +/- SEM Dose (mg/kg) CmaxSteady state Cmin2 weeks post final dose 501114.37 ± 54.881621.36 ± 310.351292.29 ± 67.82 10219.21 ± 33.66273.67 ± 17.35188.35 ± 5.48 325.03 ± 8.463.45 ± 0.82<LLQ 15.72 ± 4.98<LLQ 0.3<LLQ Supplemental Figure S6 B.

7. Supplementary Figure S7 B. A. C.

8. Supplementary Figure S8 Cytoskeletal reorganization and migration Tumor growth and metastasis APC Tumor Cells Endothelial Cells T cells Tumor Associated Macrophage Tumor Cells PLXNB1 Proteolytic cleavage by MT1-MMP Transactivation ErbB2 MET PDZ- RhoGEF/ or RhoGAP RhoA P SEMA4D 1 2