1. Severe sepsis and Septic Shock

3. Anaphylactic shock Hypovolemic shock Cardiogenic shock Neurogenic shock Septic Shock

6. Bacteremia – bacteria in blood Septicemia – bacteremia with symptoms Systemic inflammatory response syndrome (SIRS) - fever (>38C) or hypothermia (<36C) - tachypnea (>24 breaths/min) - tachycardia (HR of >90/min) - leukocytosis (>12 000/ul) - leukopenia ( 10% bands Sepsis – SIRS that has a proven or suspected mirobial etiology - Elevation of procalcitoin: marker for progression to severe sepsis Septic Shock – Sepsis + hypotension Multiple organ dysfunction syndrome (MODS) – dysfunction of more than one organ, as a complication of sepsis.

7. Chronic disease (Diabetes Mellitus, Chronic renal failure, Chronic Liver failure) Immunodeficient people (HIV, AIDS, SCID, transplant recipient, autoimmune diseases) Elderly Trauma (open wounds) Hospital acquired (IV-catheters, surgical wounds)

8. 1.Hemodynamic management Maintain BP and vital organ perfusion and function. 2. Eradicate the infection Apropriate antimicrobial therapy 3. Inhibition of action of inflammatory mediators.