1. Antibody mediated hypersensitivity reaction (type II) PhD. kefah F. hassoon 2014

2. Characters : ۩ Author name Cytotoxic Reactions ۩ Involve activation of complement by IgG or IgM binding to an antigenic cell.

3. Characteristic features Primed IgG or IgM + Antigen on membrane Injury and dysfunction of target cells

4. Type II hypersensitivity role of complement and phagocytes

5. Common disease of type II hypersensitivity 1 )HTR ( Hemolytic Transfusion Reactions) Hemolysis : mismatch of ABO blood group,severely destroy RBC.

6. 2) Hemolytic disease of newborn (HDN) Due to Rh incompatibility. Mother Rh -, first baby Rh + (Ab), second baby Rh +, fetal RBC destroyed

7. Prophylaxis Inject Anti-RhD Abs mothers (immediately after delivery) Prevents sensitization

8. 3) (ADCC) like: Drug Induced Hemolytic Anemia Occurs when an antibiotic forms a complex with red blood cell membrane protein, Induces formation of antibodies. Activation Complement. Penicillin hemolytic anemia sulphonamides thrombocytopenic purpura

9. thank you