1. Wang TINS 2001 Wang et al PNAS 2004 Wang Neuron 2002 400ms

2. Lorente de Nó’s reverberatory circuit Levitt et al 1993 Kritzer and Goldman-Rakic 1995 Pucak et al 1996

3. Summary Working memory storage and decision-making computations: shared microcircuit mechanisms in a local cortical (e.g. prefrontal, parietal, premotor) area. Coherent fast oscillation may be a common signature of the engagement of strongly recurrent network dynamics. Detection of threshold-crossing: a mode of communication between brain areas, for gating information flow or selecting a motor action. Reward-gated Hebbian plasticity in a decision network: a cellular basis of flexible sensori-motor mapping.

4. Probabilistic decision-making in a visual motion two-alternative forced choice task

5. W Newsome

6. Roitman and Shadlen 2002

7. 2-population excitatory and inhibitory neurons (integrate- and-fire or conductance-based Hodgkin-Huxley neurons) Biologically realistic synaptic kinetics (AMPA, NMDA and GABA A ) Structured network connectivity Brunel & Wang JCNS2001 Wang Neuron 2002

8. Dynamical stability and NMDA/AMPA ratio at the recurrent synapses CD R Wang J Neurosci 1999 Compte, Brunel, Goldman-Rakic, Wang Cereb Cortex 2000 Brunel and Wang J Neurophysiol 2003

9. 2-population excitatory and inhibitory neurons (integrate- and-fire or conductance-based neurons) Biologically realistic synaptic kinetics (AMPA, NMDA and GABA A ) Structured network connectivity Brunel & Wang JCNS2001 Wang Neuron 2002

10. MT output

11. Reaction Time Simulations

12. Model Data

13. Data by J Roitman, J Ditterich and M Shadlen Reaction time decreases with increasing coherence Weber's Law

14. Scale-invariance of the reaction time distributions c’=51.2%c’=0%

15. Integrate-and-Decide (diffusion) Model J Schall (Nature Rev Neurosci 2001) But how is threshold-crossing readout by downstream neurons?

16. Flexible sensori-motor association (with Stefano Fusi)

17. Flexible Sensori-motor Association (Asaad, Rainer and Miller Neuron 1998, Wise and Murray TINS 2000)

18. Locus and biophysical basis of reward-gated synaptic plasticity?

19. Summary Working memory storage and decision-making computations: shared microcircuit mechanisms in a local cortical (e.g. prefrontal, parietal, premotor) area. Coherent fast oscillation may be a common signature of the engagement of strongly recurrent network dynamics. Detection of threshold-crossing: a mode of communication between brain areas, for gating information flow or selecting a motor action. Reward-gated Hebbian plasticity in a decision network: a cellular basis of flexible sensori-motor mapping.