1. 560 585 588 613 616 641 644 669 1 200 400 600 706 (aa) 22129 BTB domain Zinc-finger domains BCL6 Number of samples mutated Number of mutations per 10 amino acids 0 100 200 300 400 500 600 700(aa) 0 2 4 6 8 10 Liu et al. Supplementary Figure 1 P<0.05 P>0.05 a b c

2. 1 100 200 300 400 500 600 673 (aa) 25 125 532555561584589 610 (aa) BTB domain Zinc-finger domains PLZF (ZBTB16) Number of samples mutated Number of mutations per 10 amino acids 0 100 200 300 400 500 600 700(aa) 0 1 2 3 4 5 P<0.05 P>0.05 a b c Liu et al. Supplementary Figure 2

3. PGL3-PKM Con WT P14S S22R R49H K60R D78E R112C P184S Q322L S326L S357R R377L C387F I391L R399L R402H T403N H404R G406V P409S C412Y K424N K424T R430W T461M L463M Y466D A522T E541K G562DD576V pGL3- PKM Luc/Rennila * * * * * * * * * * * * * BTB domain Zinc-finger domains Liu et al. Supplementary Figure 3