1. AD Lab Andrews-Dalkilic Data Exploration

2. AD Lab Outline Architecture What is Bioinformatics? Explore some bioinformatics problems and tools Talk about what’s in store for us

3. AD Lab Architecture Knowledge Base RULES Working Memory FACTS Explanation Knowledge Acquisition INFERENCE ENGINE AGENDA UI

4. AD Lab Architecture Knowledge Acquisition A (semi)automatic way to add domain knowledge (rules) without having to be a programmer We can create rules—but virtually no facility to explain how and why.

5. AD Lab Architecture Factoids Rule-based Systems Rules Post Production Efficient Pattern Matching Inference Engine RHS Execution Conflict Resolution Markov Rete Bayesian

6. AD Lab Architecture Post Production

7. AD Lab Architecture Premises (facts) Axiomization & Inference Rules build tear apart Bertrand Russell said, ``The point of philosophy is to start with something so simple as not to seem worth stating, and to end with something so paradoxical that no one will believe it.''

8. AD Lab Architecture Premises (facts) Questions: Are these facts consistent? existing systems Is this model consistent with the data? existing systems

9. AD Lab Architecture Axiomization & Rules build tear apart Axiomization is meta-language over the facts Any new facts are consistent with existing facts No “new” facts can be found…

10. AD Lab Architecture Premises (facts) Axiomization & Inference Rules Querying (with a new [partial] fact) What in my database makes my fact true? What is known about my fact?

11. AD Lab

12. Bon Voyage Summary 1 st pass—deduction (simple) 2 nd pass—fuzzy 3 rd Bayesian belief network