1. DNA Replication Copying the genetic code

2. DNA Replication  Unpack the Chromosomes  Unzip the DNA  Base pairing at the replication fork  Leading strand vs Lagging strand

3. Making Copies

5. copycopied during cell division Sister Chromatids (identical copies)

7. Accessing the DNA inactive DNA (deactivated or mitotic) DNA in use

8. Accessing the DNA

10. DNA Structure

11. Complementary Base Pairing

13. Identical Parent and Daughter Strands

14. Replication Bubbles helicase 5’ 3’ 5’

15. Replication Bubbles 5’ 3’ 5’

16. Replication Bubbles 5’ 3’ 5’

17. Replication Bubbles copies Replication Fork 5’ 3’ 5’

18. Replication Bubbles

19. Releasing the Tension

20.  Topoisomerase cleaves and uncoils DNA ahead of helicase  Single-stranded DNA binding proteins (SSB) prevent DNA from coiling back up

21. DNA Replication Primase RNA primer DNA Polymerase III 5’ 3’ 5’

22. DNA Replication  The leading strands grow toward the replication fork Leading Strands 5’ 3’ 5’

23. DNA Replication 5’ 3’ 5’

24. DNA Replication Lagging Strands  The lagging strands grow away from the replication fork 5’ 3’ 5’

25. DNA Replication 5’ 3’ 5’ DNA Polymerase I DNA Ligase

26. DNA Repliaction 5’ 3’ 5’

27. DNA Repliaction Okazaki Fragments 5’ 3’ 5’