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Necator americanus and Ancylostoma duodenale.  It has been estimated that greater than 2 billion people are infected with soil- transmitted helminths.

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Presentation on theme: "Necator americanus and Ancylostoma duodenale.  It has been estimated that greater than 2 billion people are infected with soil- transmitted helminths."— Presentation transcript:

1 Necator americanus and Ancylostoma duodenale

2  It has been estimated that greater than 2 billion people are infected with soil- transmitted helminths  880 million are children  Up to 740 million are infected with Hookworms  Warm, moist regions  Regions of poor sanitation  Regions lacking proper water filtration  Thrive in impoverished regions

3 Proportion of children who qualify for protective drug treatment

4  Diarrhea  Loss of appetite  Malaise  Intestinal obstructions  Initial itching or rash at the site of penetration  Intestinal bleeding leading to anemia and iron loss  Reduced absorption of micronutrients and proteins  Cognitive impairments and the stunting of growth

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6 They average a length of 500-600 µm.

7 Stool samples conducted over three consecutive days and plated on two different agar plates for prevalence measurements.

8 Eggs have an average length and width of 60-75 µm by 35-40 µm

9  Albendazole  Mebendadole  Pyrantel pamoate  Iron supplements if anemic

10  Multi-drug therapy to combat several STH  Preventative therapy for at risk communities  WHO recommends once a year treatment for communities with greater than 20% prevalence and twice a year for greater than 50%  More benefits in pregnancy than the alternative

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12  Knopp S, Mgeni AF, Khamis IS, Steinmann P, Stothard JR, et al. (2008) Diagnosis of Soil-Transmitted Helminths in the Era of Preventive Chemotherapy: Effect of Multiple Stool Sampling and Use of Different Diagnostic Techniques. PLoS Negl Trop Dis 2(11): e331. doi:10.1371/journal.pntd.0000331  Ndibazza J, Mpairwe H, Webb EL, Mawa PA, Nampijja M, Muhangi L, et al. Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. PLoS One (2012) 7(12):e50325.10.1371/journal.pone.0050325  http://www.who.int/intestinal_worms/en/ http://www.who.int/intestinal_worms/en/  http://www.ncbi.nlm.nih.gov/pubmed/23598487 http://www.ncbi.nlm.nih.gov/pubmed/23598487  http://en.wikipedia.org/wiki/Pyrantel_pamoate http://en.wikipedia.org/wiki/Pyrantel_pamoate  http://www.rxlist.com/albenza-drug.htm http://www.rxlist.com/albenza-drug.htm  http://www.cdc.gov/parasites/hookworm/biology.html http://www.cdc.gov/parasites/hookworm/biology.html


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