1. P. Szulc, F. Duboeuf, R. Chapurlat INSERM UMR1033, Université de Lyon, Lyon, France High subcutaneous fat measured by DXA is associated with low grip strength and poor physical capacity in older men – the STRAMBO study

2. Introduction - the association of sarcopenia (low muscle mass) with obesity is characterized by dynapenia (low muscle strength) and poor physical capacity - the association of visceral or subcutaneous fat with muscle strength and physical capacity is not clear

3. Aim Our aim was to assess the association of subcutaneous and visceral fat mass with grip strength and physical capacity in older men

4. - 897 men aged 50 and older - regional body composition (Hologic Discovery A) gynoid fat android fat – abdominal subcutaneous fat + visceral fat upper limb relative appendicular skeletal muscle mass = lean mass of upper limbs / (height) 2 lower limb relative appendicular skeletal muscle mass = lean mass of lower limbs / (height) 2 - grip strength - chair stands and clinical tests of static and dynamic balance – score of physical function of lower limbs Subjects and Methods

5. Grip strength according to body mass index <25.0 25.0-27.1 27.1-29.7 ≥29.7 (kg/m 2 ) (kPa) p for trend =0.05 p<0.05 -6.9% 0.30 SD

6. Grip strength according to fat mass gynoid fatandroid fat (kPa) p for trend <0.05 p for trend =0.06 -5.7%, 0.24SD, p<0.05 3.92 -3.33-3.92 (kg) 2.76 -2.22 -2.76 (kg)

7. Grip strength according to abdominal fat subcutaneous fatvisceral fat (kPa) p for trend =0.005 p for trend =0.23 -5.6%, 0.24SD, p<0.05 1.39 -1.13-1.39 (kg) 0.97 -0.74 -0.97 (kg)

8. Risk of poor physical function according to body mass index <25.0 25.0-27.1 27.1-29.7 ≥29.7 (kg/m 2 ) 1 OR (95%CI) p for trend <0.001

9. Poor physical function according to fat mass gynoid fatandroid fat OR (95%CI) p for trend <0.001 p for trend =0.17 3.92 -3.33 -3.92 (kg) 2.76 -2.22 -2.76 (kg)

10. Poor physical function according to abdominal fat subcutaneous fatvisceral fat OR (95%CI) p for trend <0.01 p for trend =0.62 1.39 -1.13-1.39 (kg) 0.97 -0.74 -0.97 (kg)

11. Conclusions In older men, higher subcutaneous fat is associated with lower grip strength and poor physical capacity of the lower limbs, whereas higher visceral fat is not