1. Table 7.1.1: Types of Tissue Allografts Supplied by USM Tissue Bank in 2007 Types of Tissue AllograftNo. (pieces) DF Femur2 DF Femoral head65 DF Humerus2 DF Tibia4 DF Radius0 DF Ulna0 FD Cancellous2 FD Cortical0 FD Cortico-cancellous0 Other FD Bones8 Patella2 Achilles2 Other tendon / fascia / cartilage3 Amniotic membranes175 TOTAL265 DF – Deep-frozen FD – Freeze-dried

2. Table 7.1.2: Hospitals/Other Sectors Using Bone/Tendon Allografts in 2007 USM Tissue Bank No. (pieces) Ministry of Health Hospitals Hospital Sultanah Aminah, Johor Bahru1 Hospital Melaka3 Hospital Pulau Pinang10 Hospital Raja Permaisuri Bainun, Ipoh3 Hospital Sultanah Bahiyah, Alor Setar2 Hospital Umum Sarawak, Kuching6 Queen Elizabeth Hospital, Kota Kinabalu2 TOTAL27 University Hospitals HUKM5 HUSM3 TOTAL8 Private and other sectors Amin Dental Surgery, Johor Bahru5 Chong Dental Surgery, Seri Kembangan Selangor1 Hospital Fatimah, Ipoh2 Hospital Sultan Ismail, Johor Bahru2 Hospital Tawakal, Kuala Lumpur3 Johnson & Johnson Medical2 Kemajuan Abadi Sdn. Bhd.2 Klinik Pergigian Chong, Tangkak, Johor1 Normah Medical Center, Kuching1 Stryker12 Zimmer21 TOTAL52

3. Table 7.1.3: Hospitals/Other Sectors Using Amniotic Membranes in 2007 USM Tissue Bank No. (pieces) Ministry of Health Hospitals Hospital Kuala Lumpur40 Hospital Sultan Ismail, Johor Bahru50 Hospital Miri, Sarawak5 Hospital Sultanah Bahiyah, Alor Setar7 Hospital Pulau Pinang3 Hospital Sultanah Nurzahirah, Kuala Terengganu5 Hospital Sungai Buloh, Selangor21 Hospital Teluk Intan, Perak4 Hospital Raja Perempuan Zainab II, Kota Bharu2 Hospital Umum Sarawak, Kuching6 Hospital Queen Elizabeth, Kota Kinabalu1 TOTAL144 University Hospitals HUKM7 HUSM7 IIUM6 TOTAL20 Private and other sectors Puteri Specialist Hospital, Johor Bahru5 ISEC Sdn. Bhd.2 Kuala Terengganu Specialist Center, Kuala Terengganu3 Putra Medical Centre, Alor Setar1 TOTAL11

4. Table 7.2.1: Distribution of Reporting Centre by Year Centre 2004200520062007 TOTAL No. Orthopaedics Department Department of Orthopaedics, HUSM172111 Department of Orthopaedic Surgery, UMMC10001 Institute of Orthopaedics & Traumatology, HKL20002 Department of Orthopaedics, Hospital Ipoh01001 Department of Orthopaedics, Hospital Kota Bharu930012 Department of Orthopaedics, Hospital Umum Sarawak10102 Department of Orthopaedics, Hospital Sultanah Aminah, Johor Bahru01001 Wan Orthopaedic, Trauma & Sports Injury Centre (WOTSIC), Seremban Specialist Hospital00202 Department of Orthopaedics, Hospital Island, Penang01001 Department of Orthopaedics, Hospital Fatimah, Ipoh03014 Department of Orthopaedics, Hospital Kuantan00011 Department of Orthopaedics, Kota Bharu Medical Centre00202 Department of Orthopaedics, Hospital Pulau Pinang00011 Normah Medical Specialist Centre, Kuching01001 Spine Unit, HUSM00101

5. Centre 2004200520062007 TOTAL No. Ophthalmology Department Department of Ophthalmology, Hospital Tengku Ampuan Rahimah, Klang11002 Department of Ophthalmology, Hospital Tengku Ampuan Afzan, Kuantan11002 Department of Ophthalmology, Hospital Teluk Intan00101 Department of Ophthalmology, HKL00232043 Department of Ophthalmology, Hospital Alor Setar00101 Department of Ophthalmology, Hospital Sungai Buloh00099 Department of Ophthalmology, Sri Kota Medical Centre01001 Department of Ophthalmology, HUSM00123 Others Department Maxillofacial Surgery, HUSM11002 Timberland Medical Centre01001 Sri Kota Medical Centre, Klang00101 Pantai Medical Centre, Kuala Lumpur00011 TOTAL17223536110

6. Table 7.3.1: Distribution of Patients by Gender Gender 2004200520062007TOTAL No.% % % % % Male 95310452777215867 61 Female 8471255823154243 39 TOTAL 17100221003510036100110 100 Table 7.3.2: Distribution of Patients by Ethnic Group Ethnic Group 2004200520062007TOTAL No.% % % % % Malay11651464267418506963 Chinese31852372012332725 Indian16151341176 Bumiputra Sabah0000000000 Bumiputra Sarawak1600001322 Others1629131354 TOTAL17100221003510036100110100 Table 7.3.3: Distribution of Patients by Age Group

7. Age Group 2004200520062007TOTAL No.% % % % % 0-9 0015411514109 10-19 166272613109 20-39 95362716468223935 40-59 52931482311302725 ≥60 16523411 312119 Missing 1615130033 TOTAL 17100221003510036100110100 Mean 3534364237 SD 1322192320 Median 3326354936 Min 157000 Max 6075 80 Table 7.3.3: Distribution of Patients by Age Group

8. Table 7.3.4: Distribution of Patients by Diagnosis Warranting Tissue Graft Transplantation Diagnosis 2004200520062007TOTAL No.% % % % % Congenital deformity1500131333 Infection0000383865 Trauma52815616131312 Degenerative disease15210001344 Tumour-benign52842013131110 Tumour-malignant00630130076 Burn0015250033 Scald0000130011 Sports injury0015001322 Failed primary surgery15210132565 Ophthalmological000016427192320 Others52831561620543430 TOTAL18100201003810037100113100 Note: 5 patients with 2 diagnosis and 2 missing diagnosis.

9. Table 7.4.1: Distribution of Patients According to Tissue Provider Name Tissue Bank 2004200520062007TOTAL No.% % % % % USM Tissue Bank13761882318934949687 Bone Bank, UMMC1600000011 Bone Bank, HKL31800000033 Eucara Pharmaceutical0000260022 Osteo Tech Inc0015000011 Missing00314262676 TOTAL17100221003510036100110100 Table 7.4.2: Distribution of Patients by Origin of Tissue Graft Origin of Tissue Graft 2004200520062007TOTAL No.% % % % % Local171001568318934949788 Imported00314260055 Missing00418262687 TOTAL17100221003510036100110100

10. Table 7.4.3: Distribution of Tissue Graft Used by Type Tissue Graft Type 2004200520062007TOTAL No.% % % % % Deep-frozen tissues Femur 325310000065 Femoral Head 2171241267182320 Humerus 00143100044 Tibia 1714130033 Radius 2175 000076 Freeze-dried/ Air-dried Amniotic membranes 217310257831826155 Not Available 21727000044 Missing 0027130033 TOTAL 12100291003210038100111100 Table 7.4.4: Distribution of Type of Sterilisation of the Graft Type Graft Sterilisation 2004200520062007TOTAL No.% % % % % Gamma Irradiation16941568308627758880 Glycerol0000260022 Sterile Freeze Dried Bone0015000011 Missing16627389251917 TOTAL17100221003510036100110100

11. Table 7.4.5: Distribution of Mode of Transport Storage to Recipient Hospital during Transportation Mode of Transport Storage to recipient hospital 2004200520062007TOTAL No.% % % % % By Flight1615262565 By Courier212314246923645247 By Hand42483613001312 Dry Ice Box529418000098 Sterile package0000260022 Missing52962761711312826 TOTAL17100221003510036100110100 Table 7.4.6: Distribution of Temperature of Storage during Transportation Temperature of storage during transportation ( o C) 2004200520062007TOTAL No.% % % % % -8021200000022 -400015000011 -20423418001398 -1000627261398 021200000022 370000260022 Room Temperature3184 257122615449 Missing63573261712333128 TOTAL17100221003510036100110100

12. Table 7.5.1: Distribution of Mode of Storage in Recipient Hospitals Mode of storage in recipient hospital 2004200520062007TOTAL No.% % % % % Refrigerator0015257128785449 Deep freezer-20 o C00314263887 Deep freezer-40 o C1629000033 Deep freezer-80 o C3184 131398 Glycerol00153941187 Room temperature0015130022 Others127152326001917 Not available1600000011 Missing00523130066 TOTAL17100221003510036100110100 Table 7.5.2: Distribution of Additional Tissue Usage (Composite Graft) Additional tissue usage (composite graft) 2004200520062007TOTAL No.% % % % % No6351255329133928375 Yes95373213251917 Not available21215000033 Missing0029261355 TOTAL17100221003510036100110100

13. Table 7.5.3: Distribution of Type of Additional Tissue Used (Composite Graft) Type of additional tissue used (composite graft) 2004200520062007TOTAL No.% % % % % Autografts77834300001053 Allografts11122911002 632 Others1111140000210 Missing00114000015 TOTAL91007 1 2 19100 Table 7.5.4: Distribution of Presence of Pre Operative Infection at Implant Site Presence of pre operative infection at implant site 2004200520062007TOTAL No.% % % % % No15882195318927759485 Yes00004119251312 Not Available21200000022 Missing0015000011 TOTAL17100221003510036100110100 Table 7.5.5: Distribution of Pre Implant Graft Culture Swab Pre implant graft culture swab 2004200520062007TOTAL No.% % % % % No15881673174922617063 Yes0015001322 Not Available212006175141312 Missing0052312348222523 TOTAL17100221003510036100110100

14. Table 7.5.6: Distribution of Type of Infection of Pre Implant Graft Type of infection of pre implant graft 2004200520062007TOTAL No.% % % % % Cytomegalovirus0011000000150 Proteus0000001100150 TOTAL001100001 2 Table 7.5.7: Distribution of Grafts Soaked in Antibiotics Prior to Transplantation Grafts soaked in antibiotics prior to transplantation 2004200520062007TOTAL No.% % % % % No847523288028786962 Yes74116736176 3532 Not Available21200130033 Missing0015002533 TOTAL17100221003510036100110100 Table 7.5.8: Distribution of Antibiotics Used to Soak the Grafts in Prior to Transplantation Antibiotics used to soak the grafts in prior to transplantation 2004200520062007TOTAL No.% % % % % Ceftriazone457956350001646 Gentamycin3434253504661440 Ceftriazone and Gentamycin00000011713 Vancomycin, Postome iodine0016000013 Povidone iodine, Ceftriazone0016000013 Missing00160011725 TOTAL7100161006 6 35100

15. Table 7.5.9: Distribution of Patients by Systemic Antibiotics Given Prior to Transplantation Systemic antibiotics prior to transplantation 2004200520062007TOTAL No.% % % % % No424314267426725954 Yes1271177792610284843 Not Available1600000011 Missing0029000022 TOTAL17100221003510036100110100 Table 7.5.10: Distribution of Patients by Type of Systemic Antibiotics Given Prior to Transplantation Type of systemic antibiotics given to patient prior to transplantation 2004200520062007TOTAL No.% % % % % Cefeperazone217212000049 Ceftriazone00001110012 Cefuroxine7587404452252044 Ciproflaxacin002120022549 Chloramphenicol00001110012 Metronidazole1816000024 Ceftazidine00001110012 Ceftriazone/Imipenam217212222225818 Ampicillin/Sulbactam00000011212 T. Augmentin00000011212 T. Flurariazole00212000024 Missing0016000012 TOTAL12100171009 8 46100