1. 1 ORAL AND GASTROINTESTINAL DISEASES CHAPTER 22

2. 2 Anatomy Review Mouth Stomach Small Intestine

3. 3 GIT Review Large Intestine harbors most bacteria. Food can hang out here for 60 hours or more. Normal microflora Bacteriodes, E. coli, Clostridium

4. 4 Oral Cavity Bacterial Diseases Dental Plaque “biofilm” Streptococcus mutans and sanguis Dental Caries Periodontal disease Tooth decay gingivitis Sorbitols, xylitols

5. 5 Oral Cavity Fungal Diseases Thrush Candida

6. 6 Gastrointestinal Bacterial Intoxications Staphylococcal Enterotoxicosis Clostridium perfringens Enterotoxicosis

7. 7 Gastrointestinal Bacterial Intoxications Botulism extreme toxicity of botulinum neurotoxin Bacillus cereus - 2-5% 0f foodborne, enterotoxin Clostridium perfringens enterotoxin Clostridium botulinum

8. 8 Bacterial Infections Enteritis Inflammation of the intestine, mild diarrhea Dysentery severe diarhea Risk of dehydration or anemia. Salmonella typhi, Vibrio cholera

9. 9 Bacterial Infectious Disease Salmonellosis chronic infection. reproduction in macrophages Typhoid Fever chronic infection of lymphatic tissue

10. 10 Bacterial Shigellosis Shigellosis extreme dysentary. Plasmid-borne virulence factors

11. 11 Bacterial Infectious Disease Asiatic Cholera Vibriosis “uncooked shellfish” Traveller’s Diarrhea enteroinvasive E.coli, Shigella, protozoa,

12. 12 Bacterial Infectious Disease more food poisoning Campylobacter poultry, microaerophilic Yersinia psychrophilic Listeria- is one of the most virulent foodborne pathogens with 20 to 30 percent of clinical infections resulting in death.

13. 13 Bacterial Upper G.I. Disease Peptic Ulcer/Chronic Gastritis

14. 14 Bacterial Biliary Tract Disease Pseudomembranous Colitis Clostrudium difficile

15. 15 Viral Gastrointestinal Disease Viral Enteritis Rotavirus, Norwalk virus (cruise ship FP)

16. 16 Viral Hepatitis Hepatitis A Hepatitis B Infectious oral, RNA Blood borne, DNA

17. 17 Hepatitis Incidence

18. 18 Viral Hepatitis Hepatitis C blood, RNA Hepatitis D co-infection with B Hepatitis E - oral, RNA

19. 19 Protozoan GI Disease — Giardiasis Giardia lamblia

20. 20 Protozoan GI Disease — Amebic Dysentery Entameba histolytica

21. 21 Protozoan GI Disease — Balantidiasis Balantidium coli

22. 22 Protozoan Gastrointestinal Disease Cryptosporidiosis fecal-oral route, cysts