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فيزيولوژي گازهاي خون شرياني Gas Exchange Partial Pressure –Each gas in atmosphere contributes to the entire atmospheric pressure, denoted as P Gases.

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Presentation on theme: "فيزيولوژي گازهاي خون شرياني Gas Exchange Partial Pressure –Each gas in atmosphere contributes to the entire atmospheric pressure, denoted as P Gases."— Presentation transcript:

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2 فيزيولوژي گازهاي خون شرياني

3 Gas Exchange Partial Pressure –Each gas in atmosphere contributes to the entire atmospheric pressure, denoted as P Gases in liquid –Gas enters liquid and dissolves in proportion to its partial pressure O2 and CO2 Exchange by DIFFUSION –PO2 is 104 mmHg in alveoli and 40 in alveolar capillaries –PCO2 is 45 in alveolar capillaries and 40 in alveoli

4 Partial Pressures Oxygen is 21% of atmosphere 760 mmHg x.21 = 160 mmHg PO2

5 Co2 N2 o2

6 160 تغييرات فشار گاز اكسيژن در طي تنفس 149

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8 104 40

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10 Haemoglobin 4 x Haem group + 4 x Polypeptide chain

11 Adaptation of RBC in transport of gases Lack a nucleus Lack a nucleus Biconcave disc Biconcave disc Lack a nucleus Biconcave disc

12 The transport of oxygen in blood - Haemoglobin Hb + 4O 2 → Hb(O 2 ) 4 Over 98% of O 2 is carried in this way

13 Oxygen Transport Method Percentage Dissolved in Plasma 1.5 % Combined with Hemoglobin 98.5 %

14 انتقال اكسيژن از خون به بافتها

15 درصد اشباع هموگلوبين ازاكسيژن درصد اشباع هموگلوبين ازاكسيژن هرگرم هموگلوبين مي تواند با 34/1 ميلي ليتر اكسيژن تركيب شود حال اگر در هر 100 سي سي خون 15 گرم هموگلوبين باشد : هرگرم هموگلوبين مي تواند با 34/1 ميلي ليتر اكسيژن تركيب شود حال اگر در هر 100 سي سي خون 15 گرم هموگلوبين باشد : در هر 100 ميلي ليتر خون 20.1=15*1.34 اكسيژن خواهيم داشت و در صد اشباع اكسيژني برابراست با : حداكثر مقدار اكسيژن كه مي تواند وحود داشته باشد / مقداراكسيژن موجود در 100 سي سي =Saturation

16 منحني تجزيه اكسي هموگلوبين artery vein

17 FACTORS AFFECTING O2-Hb DISSOCIATION CURVE PCO2TEMPERATURE 2,3 – DIPHOSPHOGLYCERATE PRESENCE/PERCENTAGE OF FETAL Hb pH

18 Partial Pressures Carbon dioxide is.04% of atmosphere Carbon dioxide is.04% of atmosphere 760 mmHg x.0004 =.3 mm Hg PCO2 760 mmHg x.0004 =.3 mm Hg PCO2 This mixes with high CO2 levels from residual volume in the alveoli to arrive at PCO2 of 40 mmHg This mixes with high CO2 levels from residual volume in the alveoli to arrive at PCO2 of 40 mmHg

19 03 تغييرات فشار گاز دي اكسيد كربن در طي تنفس 40

20 03 40 45 40

21 Co2 transported as:

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25 N2O2 CO2 H2O

26 What Is An ABG? pH[H + ] PCO 2 Partial pressure CO 2 PO 2 Partial pressure O 2 HCO 3 Bicarbonate SaO 2 Oxygen Saturation

27 What is an ABG? The Components The Components – pH / PaCO 2 / PaO 2 / HCO 3 / O 2 sat Desired Ranges Desired Ranges – pH - 7.35 - 7.45 – PaCO 2 - 35-45 mmHg – PaO 2 - 80-100 mmHg – HCO 3 - 21-27 – O 2 sat - 95-100%

28 H 2 O + CO 2  H 2 CO 3  HCO 3 + H + Acid/Base Relationship PH=6.1 +logHCO3 /.03*PCO2

29 The Terms ACIDS ACIDS –Acidemia –Acidosis Respiratory Respiratory  CO 2  CO 2 Metabolic Metabolic  HCO 3  HCO 3 BASES BASES –Alkalemia –Alkalosis Respiratory Respiratory  CO 2  CO 2 Metabolic Metabolic  HCO 3  HCO 3

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