2. Our materials

3. Freedom of choice

4. Tray

5. Gingiva Mask, Model & Model Ortho

6. Base

7. C&B and C&B MFH

8. Surgical Guide

9. Ortho Rigid, Ortho Clear & Ortho IBT

10. Cast

11. Post curing

12. Research & Development

14. Physical properties ISO en ASTM standards related to dentistry of medical devices Charpy Impact Strength Flexural Strength & Modulus Fracture Toughness Total Fracture Work Maximum Stress Intensity Factor Elongation to Break Tensile Strength Compressive Strength Vickers Hardness Shore A&D Tear Resistance Water Sorption & Solubility Residual Monomer Wear Resistance Crazing

15. Onze materialen

18. To measure is to know!

19. Output vs input

22. Biocompatibility

23. Cytotoxicity Sensitization Irritation Intracutaneos Reactivity Systemic & Subchronic Toxicity Genotoxicity Implantation Heamacompatibility Sterilisation Design Stability Wear Resistance Food Resistance Leachables Comfort Fit Biocompatibility & Clinical characteristics ISO en ASTM norms, incl. ISO 10993

24. mat Biological evaluation acc. ISO 10993 erialen

26. Clinical studies

27. Studies in cooperation with R&D partners Crown & Bridge C&B in- and onlays Splints & Retainers Orthodontic Regulators Surgical Guides Cranio Facial Devices Implants

28. R&D partners TNO Additive Manufacturing, Eindhoven ACTA – Academic Centre Dentistry University, Amsterdam VU - Medical University, Amsterdam AMC - Medical University, Amsterdam RUMC - Radboud Medical University, Nijmegen UMC – Utrecht Medical Center, Utrecht KUL – Royal University Leuven, Belgium Fontys Applied Science, Eindhoven HU Chemical Technology, Utrecht

29. Regulatory

30. Legislations worldwide Medical Device Directive – 93/42/EEC International registrations; FDA PAL CAMCDS SFDA KFDS TPG etc. Support to RA of distributors