1. 1 After 1 day of treatment 0 10 20 30 CTLFDMLIMLIH After 7 days of treatment 0 10 20 30 CTLFDMLIMLIH After 1 day of treatment 0 20 40 60 80 CTLFDMLIMLIH After 7 days of treatment 0 20 40 60 80 CTLFDMLIMLIH A:Example of STOP profile: Apo A1 B:Example of GROW profile: Vimentin Fig. 1: * ** * * *

2. 2 Molecular Weights 43 30 10 20 4.55.5 pH range Fig. 2: A B After 7 days of treatment After 1 day of treatment Vimentin Apo A1 After 7 days of treatment After 1 day of treatment

3. 3 Fig. 3: A BC D 43 30 10 20 47 pH range Molecular Weights Pooled retina samples Pooled sclera samplesIndividual retina samples

4. 4 A B C Fibrous sclera Ganglion cell layer Ganglion cell layer Fig. 4: Retina Choroid Sclera

5. 5 Fig. 5: 0 25 50 75 100 125 LIM Vehicle treatment LIM 63 µg of GW7647 LIM 189 µg of GW7647 * * Degree of myopia (%)