1. Kimiko Domoto-Reilly, MD Cognitive / Behavioral Neurology Fellow Massachusetts General Hospital & Brigham and Women’s Hospital

2. Background: ADNI  Alzheimer’s Disease Neuroimaging Initiative (2004)  natural history study of early Alzheimer’s disease  800 subjects from 50 sites across North America  control subjects and subjects with memory impairment  6-12 month evaluations over 3 years  clinical / cognitive assessments  brain scans: MRI, PET  biofluid collection: blood, urine, CSF  funded by National Institute on Aging, the Alzheimer’s Association, and multiple drug companies

3. Background: ADNI  freely shared data repository  many new insights into Alzheimer’s disease  European-ADNI (2006); Japanese-ADNI (2006); ADNI-GO (2010); ADNI II (2011); Parkinson’s Progression Markers Initiative

4. NIFD: Overview  Neuroimaging in Frontotemporal Dementia  natural history study of early FTD  215 subjects from 3 sites (UCSF, Mayo, MGH)  140 FTD subjects, 75 control subjects  here at MGH: 25 FTD subjects  6 month evaluations over 1.5 years  clinical / cognitive assessments  brain scans: MRI (and PET at other sites)  biofluid collection: blood, urine, CSF

5. NIFD: Enrollment  eligibility  diagnosis of bvFTD, PNFA, or SD  fluent in English  45-90 years old  study partner  able to undergo multiple MRIs and 2 LPs

6. NIFD: Schedule Month061218 clinical & cognitive assessments XXXX informant questionnaires XXXX MRIXXXX CSF, blood, urineXX

7. NIFD: Goals  goals  to collect multimodal data (cognitive/behavioral, imaging, biofluids) in a standardized fashion  to contribute to a shared database  to learn more about the natural history of FTD  to learn more about new imaging techniques and biofluid measurements  to learn about which information is best for diagnosis, prognosis, and monitoring  data collection funded by National Institute on Aging / National Institute of Neurological Disorders and Stroke (NIA-NINDS)

8. 4RTNI: 2012?  4R-Tau Neuroimaging Initiative  design parallels ADNI and NIFD  natural history study  imaging and biofluid collection  Tau-based diseases  corticobasal degeneration (CBD)  progressive supranuclear palsy (PSP)  study funded by an anonymous grant from a family of a patient cared for at UCSF