1. Jessica Holttum and Jordan Standlee

2.  Statistics  Molecular Biology  Symptoms  Transmission  Treatment  Infamous Strains  Conclusion

3.  5-20% of U.S. infected  200,000 hospitalized  3-5 million severe cases worldwide  250,000-500,000 deaths  300 million doses of vaccine administered worldwide Source: cdc.gov

4.  Enveloped virus  HA and NA proteins  Hemagglutinin  Neuraminidase  “H1N1”  3 subtypes  A – animals/humans  B – humans only  C - asymptomatic Source: www.micro.magnet.fsu.edu

5.  (-) ssRNA genome  ~14,000nt total; 8 segments Source: www.virology.ws

6.  Last about a week  1-2 day incubation  May include:  Fever/chills  Cough  Sore throat  Runny/stuffy nose  Muscle/Headaches  Fatigue  Vomiting/diarrhea Source: newshealth.net

7.  Bacterial pneumonia  Ear/sinus infections  Bronchitis  Worsening of preexisting conditions  Asthma  Diabetes  Congestive heart disease  Link to schizophrenia

8.  Inhalation of infected fluid particles  Hand-to-mouth contact  Flu “season”  Not due to temperature  Bad weather  people stay indoors  extended close contact with others Source: shanghaiist.com

9.  Rest  Vitamin C & A  Fluids  Hot drinks/soup  OTC Medication  Antivirals  Prevention  Avoid crowds  Cover coughs, sneezes  Wash hands  Skip school/work Source: recipesfromhome- online.com

10.  2 types  TIV Injection Dead virus  LAIV Nasal spray Attenuated virus Cold-adapted Source: IFPMA

11.  H1N1  1/3 world population infected  30-50 million dead  675,000 in U.S.  Over half were age 20-40  Transmission linked to high humidity  3 waves in one year  Spring 1918  Fall 1918  Winter 1918-1919  “Mother of all pandemics” Source: 1918.pandemicflu.gov

12.  H5N1  First detected 1996  Human detection 1997  Outbreak begins 2003  Rare in humans; common in birds  Attacks lower respiratory tract  ~60% mortality  Expected to remain in circulation Source: hogueprophecy.com

13.  H1N1  Less virulent  Quadruple reassortant  First case 2009, California  Public Health Emergency expired 6/23/10  Likely to continue seasonal spread Source: freewebs.com

14.  http://www.cdc.gov/flu/professionals/vaccination/vax-s http://www.cdc.gov/flu/professionals/vaccination/vax-s  http://www.cdc.gov/flu/about/viruses/types.htm http://www.cdc.gov/flu/about/viruses/types.htm  http://www.cdc.gov/flu/keyfacts.htm http://www.cdc.gov/flu/keyfacts.htm  http://www.cdc.gov/flu/weekly/ http://www.cdc.gov/flu/weekly/  http://www.cdc.gov/h1n1flu/cdcresponse.htm http://www.cdc.gov/h1n1flu/cdcresponse.htm  http://www.cdc.gov/flu/about/qa/hospital.htm http://www.cdc.gov/flu/about/qa/hospital.htm  http://www.cdc.gov/media/pressrel/2010/r100224.htm http://www.cdc.gov/media/pressrel/2010/r100224.htm  http://www.cdc.gov/flu/about/qa/fluvaccine.htm http://www.cdc.gov/flu/about/qa/fluvaccine.htm  http://www.cdc.gov/flu/avian/outbreaks/current.htm http://www.cdc.gov/flu/avian/outbreaks/current.htm  http://www.cdc.gov/ncidod/eid/vol12no01/05-0979.htm http://www.cdc.gov/ncidod/eid/vol12no01/05-0979.htm  http://virus.stanford.edu/uda/ http://virus.stanford.edu/uda/  http://1918.pandemicflu.gov http://1918.pandemicflu.gov  http://micro.magnet.fsu.edu/cells/viruses/influenzavirus.html http://micro.magnet.fsu.edu/cells/viruses/influenzavirus.html  http://biology.kenyon.edu/BMB/Chime2/2005/Cerchiara- Holsberry/FRAMES/start.htm http://biology.kenyon.edu/BMB/Chime2/2005/Cerchiara- Holsberry/FRAMES/start.htm

15.  http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of _the_month/pdb113_1.html http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of _the_month/pdb113_1.html  http://www.ifpma.org/Influenza/index.php?id=4234 http://www.ifpma.org/Influenza/index.php?id=4234  http://health.nytimes.com/health/guides/disease/the- flu/treatment.html http://health.nytimes.com/health/guides/disease/the- flu/treatment.html  http://www.who.int/csr/disease/swineflu/notes/h1n1_vaccine_20090806 /en/index.htmlummary.htm http://www.who.int/csr/disease/swineflu/notes/h1n1_vaccine_20090806 /en/index.htmlummary.htm  http://www.who.int/mediacentre/factsheets/fs211/en/index.html http://www.who.int/mediacentre/factsheets/fs211/en/index.html  http://www.who.int/csr/don/2009_04_24/en/index.html http://www.who.int/csr/don/2009_04_24/en/index.html  http://www.who.int/csr/disease/avian_influenza/2011_01_24_h5n1_avia n_influenza_timeline_updates.pdf http://www.who.int/csr/disease/avian_influenza/2011_01_24_h5n1_avia n_influenza_timeline_updates.pdf  http://www.virology.ws/2009/05/01/influenza-virus-rna-genome/ http://www.virology.ws/2009/05/01/influenza-virus-rna-genome/  http://www.sciencedaily.com/releases/2004/08/040803100609.htm http://www.sciencedaily.com/releases/2004/08/040803100609.htm  http://www.medicalnewstoday.com/articles/142829.php http://www.medicalnewstoday.com/articles/142829.php  http://www.ncbi.nlm.nih.gov/pubmed/21307188 http://www.ncbi.nlm.nih.gov/pubmed/21307188  http://www.nlm.nih.gov/medlineplus/ency/article/000080.htm http://www.nlm.nih.gov/medlineplus/ency/article/000080.htm  http://www.nlm.nih.gov/medlineplus/flu.html http://www.nlm.nih.gov/medlineplus/flu.html