1. EUROPEAN RESEARCH AND INNOVATION OFFICE 4 th FLUTCORE Progress Meeting September 23 rd 2015 – London WP9 - Project Management Amelie Guisseau UCL European Research and Innovation Office a.guisseau@ucl.ac.uk 4 th FLUTCORE Progress Meeting September 23 rd 2015 – London WP9 - Project Management Amelie Guisseau UCL European Research and Innovation Office a.guisseau@ucl.ac.uk

2. Project Management Period 1 (M1-M18) Report update Finance summary Project deliverables (Period 2) Dissemination reminders

3. Period 1 report

4. Periodic Report 1 ( September 2013 – February 2015) Period 1 report submitted on 30/04/2015 (within the deadline) Administrative & scientific comments received 08/05/2015 Responses from the consortium were sent on 11/05/2015 Payment for the first reporting period was received on 08/06/2015 and distributed to partners in July A big thank you to you and your colleagues for your excellent collaboration with this report!

5. Finance summary Total costs declared and accepted in P1: €1,347,812.37 Accepted EC contribution for P1: €1,032,774.02 Interim Payment of €1,032,774.02 received on 08/06/2015 We have now received (Pre-financing + Interim Payment 1) ~ 65% of the project’s total EC contribution The next payment - following approval of Period 2 report (~November 2016) - will be limited to 85% of the maximum EC contribution. The remaining 15% will be paid at the end of the project (i.e. balance between the total accepted eligible costs minus the amounts already paid) All partners have to anticipate a negative cash flow at the end of the project!

6. Project monitoring

7. Interim reporting (M19-M24)

8. Annex 1: Personnel: 40% Subcontracting: 13% Consumables: 18% Travels: 1% Other: 3% Indirect: 25% 2% 32% 40% 16%8%

9. Interim reporting (M19-M24) 108% 0% 4% 1% 62% 39% 68% 122% 4%

10. Project monitoring & where we are at M25 Y2 deliverables pending Y3

11. Pending deliverables: due M24 D1.5, Robust method for efficient purification of recombinant VLPs suitable for transferring to a contract manufacturer – to be delivered shortly after the Tech transfer run at UCL D3.4, Identification of the most immunogenic/protective VLP-NP construct in mice – put on hold – D3.5, Go/NoGo decision based on a short list of the most immunogenic/protective VLP-HA/M2/NP in mice – completed, to be submitted shortly D3.6, Identification of a protective CDR3 heavy chain signature in B cells – to be delivered end of September D3.7, Identification of the protective TCR usage signature – to be delivered end of September D4.1, Demonstration of efficacious prophylactic regimen of best candidate VLP in ferrets – WP4 start delayed D4.2, Clinical lead candidate selected – WP4 start delayed D5.1, Technical transfer documentation – in process, to be delivered shortly after the Tech transfer run at UCL.

12. Plan for Y3: deliverables up to M30 D2.4, Long-term stability data for VLPs D5.2, MCB and WCB generated and fully characterised D5.3, material made available for (a) preclinical toxicology (b) seroconversion and (c) structural analysis D6.1, Final version of trial protocol as submitted to Ethical committee D6.2, Preclinical safety report D6.3, Regulatory application D6.4, Appointment of the Ethics Advisor D8.3, Exploitation plan – draft to be circulated by end of September

13. Dissemination

14. Dissemination: reminders The project exploitation plan is due in September Visibility of EU funding: All publications or any other dissemination relating to foreground must –Display the EU emblem (flag) –Include the following text The research leading to these results has received funding from the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement n° 602437. All dissemination activities related to FLUTCORE must be listed on the participant portal

15. Publications At least 45 days prior notice of any dissemination activity shall be given to the other beneficiaries concerned Special clause 39: Open Access –a machine-readable electronic copy of the published version or final peer-reviewed manuscript accepted for publication shall be deposited in a repository (institutional or subject-based) for scientific publications as soon as possible and at the latest on publication –Open access to the deposited publication — via the repository — must be provided at the latest: (i) on publication, if an electronic version is available for free via the publisher, or (ii) within six months of publication Please consult within your organisation – UCL has a dedicated office supporting researchers with making their work open access

16. Amelie Guisseau European Project Manager European Research & Innovation Office (ERIO) University College London Maple House, 149 Tottenham Court Rd, 7th Floor London W1T 7NF – United Kingdom a.guisseau@ucl.ac.uk Tel: +44 (0)20 7679 9635 Thank you for your attention!