1. Supplemental Figure 1. A. GCN1L1B. DSPC. RCN3 D. AKR1B10E. PDIA4F. CTSB

2. Supplemental Figure 1. Cont. G. EIF5AH. SERPINB5I. TPD52

3. Supplemental Figure 2. A. Biological process B. Cellular component

4. Abs.  460-  690 Days A. Supplemental Figure 3. D. Sh1 Cont B. C. No FBS10%FBS +1uM IPA3 10%FBS +10uM IPA3 No FBS10%FBS +1uM IPA3 10%FBS +10uM IPA3 E. Number of cells Sh1Cont A549  -PAK2  -  actin Number of cells

5. 164 candidates 12 candidates tested with commercial Elisa 15 controls 15 SCC 15 ADC 30 candidates tested with commercial and in house-ELISAs 6 candidates 45 ADC 49 controls 9 candidates 41 SCC 34 controls 15 controls 15 SCC 15 ADC Supplemental Figure 5 Supplemental Table 11 Supplemental Table 12-15 Supplemental Figure 4.

6. Supplemental Figure 5.